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Gene Family: Mitochondrial complex IV: cytochrome c oxidase subunits (COX, MT-CO)

Also known as : "Complex IV subunits"

Cytochrome c oxidase: The enzyme cytochrome c oxidase or Complex IV, EC 1.9.3.1 ) is a large transmembrane protein complex found in bacteria and the mitochondrion of eukaryotes. It is the last enzyme in the respiratory electron transport chain of mitochondria (or bacteria) located in the mitochondrial (or bacterial) membrane. It receives an electron from each of four cytochrome c molecules, and transfers them to one oxygen molecule, converting molecular oxygen to two molecules of water. In the process, it binds four protons from the inner aqueous phase to make water, and in addition translocates four protons across the membrane, helping to establish a transmembrane difference of proton electrochemical potential that the ATP synthase then uses to synthesize ATP. [Source: Wikipedia]

Genes contained within the family: 19

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
COX4I1 cytochrome c oxidase subunit 4I1 COX4 COX4-1 16q24.1
COX4I2 cytochrome c oxidase subunit 4I2 COX4L2 COXIV-2, COX4B, dJ857M17.2, COX4-2 20q11.21
COX5A cytochrome c oxidase subunit 5A 15q24.2
COX5B cytochrome c oxidase subunit 5B 2q11.2
COX6A1 cytochrome c oxidase subunit 6A1 COX6A 12q24.31
COX6A2 cytochrome c oxidase subunit 6A2 16p11.2
COX6B1 cytochrome c oxidase subunit 6B1 COX6B COXG 19q13.12
COX6B2 cytochrome c oxidase subunit 6B2 COXVIB2, FLJ32865, CT59 19q13.42
COX6C cytochrome c oxidase subunit 6C 8q22.2
COX7A1 cytochrome c oxidase subunit 7A1 COX7A COX7AH 19q13.12
COX7A2 cytochrome c oxidase subunit 7A2 COXVIIa-L, COX7AL 6q14.1
COX7B cytochrome c oxidase subunit 7B Xq21.1
COX7B2 cytochrome c oxidase subunit 7B2 4p12
COX7C cytochrome c oxidase subunit 7C 5q14.3
COX8A cytochrome c oxidase subunit 8A COX8 COX8-2, COX8L, VIII-L, COX, VIII 11q13.1
COX8C cytochrome c oxidase subunit 8C COX8-3 14q32.12
MT-CO1 mitochondrially encoded cytochrome c oxidase I MTCO1 COX1, COI mitochondria
MT-CO2 mitochondrially encoded cytochrome c oxidase II MTCO2 COX2, CO2 mitochondria
MT-CO3 mitochondrially encoded cytochrome c oxidase III MTCO3 COX3, COIII, CO3 mitochondria