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Gene Family: Mitochondrial complex II: succinate dehydrogenase subunits (SDH)

Also known as : "Complex II subunits", "Succinate-coenzyme Q reductase subunits", "SQR subunits"

Succinate dehydrogenase: Succinate dehydrogenase or succinate-coenzyme Q reductase (SQR) or respiratory Complex II is an enzyme complex, bound to the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. It is the only enzyme that participates in both the citric acid cycle and the electron transport chain. In step 6 of the citric acid cycle, SQR catalyzes the oxidation of succinate to fumarate with the reduction of ubiquinone to ubiquinol. This occurs in the inner mitochondrial membrane by coupling the two reactions together. [Source: Wikipedia]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SDHA succinate dehydrogenase complex flavoprotein subunit A SDH2 FP, SDHF 5p15.33
SDHB succinate dehydrogenase complex iron sulfur subunit B SDH1, SDH 1p36.13
SDHC succinate dehydrogenase complex subunit C PGL3 CYB560, cybL 1q23.3
SDHD succinate dehydrogenase complex subunit D PGL, PGL1 cybS 11q23