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Gene Family: Lipocalins (LCN)

Lipocalin: The lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. They share limited regions of sequence homology and a common tertiary structure architecture. This is an eight stranded antiparallel beta-barrel with a repeated + 1 topology enclosing an internal ligand binding site. These proteins are found in gram negative bacteria, vertebrate cells, and invertebrate cells, and in plants. Lipocalins have been associated with many biological processes, among them immune response, pheromone transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions. [Source: Wikipedia]

Genes contained within the family: 19

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
LCN1 lipocalin 1 VEGP, TP, PMFA, MGC71975, TLC 9q34.3
LCN2 lipocalin 2 NGAL, 24p3 9q34.11
LCN6 lipocalin 6 9q34.3
LCN8 lipocalin 8 LCN5 9q34.3
LCN9 lipocalin 9 9q34.3
LCN10 lipocalin 10 9q34.3
LCN12 lipocalin 12 MGC48935 9q34.3
OBP2A odorant binding protein 2A OBP, LCN13, hOBPIIa 9q34.3
OBP2B odorant binding protein 2B hOBPIIb, LCN14 9q34.2
LCN15 lipocalin 15 UNQ2541, PRO6093 9q34.3
AMBP alpha-1-microglobulin/bikunin precursor ITI, ITIL UTI, HCP, EDC1, HI30, IATIL, ITILC 9q32
APOD apolipoprotein D 3q29
APOM apolipoprotein M ApoM, G3a, NG20 6p21.33
C8G complement C8 gamma chain 9q34.3
ORM1 orosomucoid 1 9q32
ORM2 orosomucoid 2 AGP-B, AGP-B', AGP2 9q32
PAEP progestagen associated endometrial protein PEP, PP14, GdA, GdS, GdF, PAEG, GD, MGC138509, MGC142288 9q34.3
PTGDS prostaglandin D2 synthase PGDS, L-PGDS 9q34.3
RBP4 retinol binding protein 4 10q23.33