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Gene Family: Killer cell immunoglobulin like receptors (KIR)

Also known as : "Killer-cell immunoglobulin-like receptors", "Killer cell immunoglobulin-like receptors"

Killer-cell immunoglobulin-like receptor: Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface proteins found on important cells of the immune system called natural killer (NK) cells. They regulate the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to detect virally infected cells or tumor cells that have a characteristic low level of Class I MHC on their surface. Most KIRs are inhibitory, meaning that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the ability to activate cells. KIR molecules are highly polymorphic, meaning their gene sequences differ greatly between individuals, so that different individuals possess different arrays/repertoires of KIR genes. [Source: Wikipedia]

Genes contained within the family: 18

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KIR2DL1 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 cl-42, nkat1, 47.11, p58.1, CD158A 19q13.42
KIR2DL2 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 cl-43, nkat6, CD158B1, CD158k 19q13.4 alternate reference locus
KIR2DL3 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 cl-6, nkat2, nkat2a, nkat2b, p58, CD158B2 19q13.42
KIR2DL4 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 103AS, 15.212, CD158D 19q13.42
KIR2DL5A killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A KIR2DL5.1, KIR2DL5, CD158F 19q13.4 alternate reference locus
KIR2DL5B killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B KIR2DL5.2, KIR2DL5, KIR2DL5.3, KIR2DL5.4 19q13.4 alternate reference locus
KIR2DP1 killer cell immunoglobulin like receptor, two Ig domains pseudogene 1 KIRZ, KIRY, KIR15, KIR2DL6 19q13.42
KIR2DS1 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 EB6ActI, EB6ActII, CD158H 19q13.4 alternate reference locus
KIR2DS2 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2 cl-49, nkat5, 183ActI, CD158J 19q13.4 alternate reference locus
KIR2DS3 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 nkat7 19q13.4 alternate reference locus
KIR2DS4 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 cl-39, KKA3, nkat8, CD158i 19q13.42
KIR2DS5 killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 nkat9, CD158G 19q13.4 alternate reference locus
KIR3DL1 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 KIR cl-2, NKB1, cl-11, nkat3, NKB1B, AMB11, CD158e1/2, CD158E1, CD158e2 19q13.42
KIR3DL2 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 cl-5, nkat4, nkat4a, nkat4b, CD158K 19q13.42
KIR3DL3 killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 KIRC1, KIR3DL7, KIR44, CD158z 19q13.42
KIR3DP1 killer cell immunoglobulin like receptor, three Ig domains pseudogene 1 KIRX, KIR48, KIR2DS6, KIR3DS2P, CD158C 19q13.42
KIR3DS1 killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 nkat10 19q13.4 alternate reference locus
KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 LENG12 FLJ00060 19q13.42

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