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Gene Family: Kelch like (KLHL)

Kelch protein: Kelch proteins (and Kelch-like proteins) are a widespread group of proteins that contain multiple Kelch motifs. The kelch domain generally occurs as a set of five to seven kelch repeats that form a beta-propeller tertiary structure. Kelch-repeat beta-propellers are generally involved in protein-protein interactions, though the large diversity of domain architectures and limited sequence identity between kelch motifs make characterisation of the kelch superfamily difficult. [Source: Wikipedia]

Genes contained within the family: 42

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KLHL1 kelch like family member 1 KIAA1490, MRP2, FLJ30047 13q21.33
KLHL2 kelch like family member 2 MAV 4q32.3
KLHL3 kelch like family member 3 KIAA1129 5q31.2
KLHL4 kelch like family member 4 KIAA1687, DKELCHL, KHL4 Xq21.31
KLHL5 kelch like family member 5 4p14
KLHL6 kelch like family member 6 FLJ00029 3q27.1
KLHL7 kelch like family member 7 KLHL6, SBBI26, RP42 7p15.3
KLHL8 kelch like family member 8 KIAA1378 4q22.1
KLHL9 kelch like family member 9 KIAA1354, FLJ13568 9p21.3
KLHL10 kelch like family member 10 FLJ32662 17q21.2
KLHL11 kelch like family member 11 FLJ10572 17q21.2
KLHL12 kelch like family member 12 C3IP1 1q32.1
KLHL13 kelch like family member 13 BKLHD2, KIAA1309 FLJ10262 Xq24
KLHL14 kelch like family member 14 KIAA1384 18q12.1
KLHL15 kelch like family member 15 KIAA1677 Xp22.11
GAN gigaxonin KLHL16, GAN1 16q23.2
KLHL17 kelch like family member 17 1p36.33
KLHL18 kelch like family member 18 KIAA0795, FLJ13703 3p21.31
KEAP1 kelch like ECH associated protein 1 INrf2, MGC9454, KIAA0132, MGC10630, KLHL19, MGC20887, MGC4407, MGC1114 19p13.2
KLHL20 kelch like family member 20 KLEIP, KHLHX 1q25.1
KLHL21 kelch like family member 21 KIAA0469 1p36.31
KLHL22 kelch like family member 22 FLJ14360, KELCHL 22q11.21
KLHL23 kelch like family member 23 MGC2610, FLJ37812, MGC22679 2q31.1
KLHL24 kelch like family member 24 DRE1, FLJ20059 3q27.1
KLHL25 kelch like family member 25 FLJ12587, ENC2, ENC-2 15q25.3
KLHL26 kelch like family member 26 19p13.11
IPP intracisternal A particle-promoted polypeptide KLHL27 1p34.1
KLHL28 kelch like family member 28 BTBD5 FLJ20081 14q21.2
KLHL29 kelch like family member 29 KBTBD9 KIAA1921 2p24.1
KLHL30 kelch like family member 30 FLJ43374 2q37.3
KLHL31 kelch like family member 31 KBTBD1 bA345L23.2, BKLHD6 6p12.1
KLHL32 kelch like family member 32 BKLHD5, KIAA1900 6q16.1
KLHL33 kelch like family member 33 14q11.2
KLHL34 kelch like family member 34 FLJ34960, RP11-450P7.3 Xp22.12
KLHL35 kelch like family member 35 FLJ33790 11q13.4
KLHL36 kelch like family member 36 C16orf44 FLJ12543 16q24.1
ENC1 ectodermal-neural cortex 1 NRPB PIG10, ENC-1, KLHL37, TP53I10 5q13.3
KLHL38 kelch like family member 38 C8ORFK36 8q24.13
IVNS1ABP influenza virus NS1A binding protein KLHL39, KIAA0850, NS-1, NS1-BP, ND1, HSPC068 1q25.3
KLHL40 kelch like family member 40 KBTBD5 SRYP, NEM8 3p22.1
KLHL41 kelch like family member 41 KBTBD10 SARCOSIN, Krp1 2q31.1
KLHL42 kelch like family member 42 KLHDC5 KIAA1340, Ctb9 12p11.22

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