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Gene Family: Kallikreins (KLK)

Kallikrein: Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein ( KLKB1 ) has no known homologue, while tissue kallikrein-related peptidases ( KLKs ) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation. [Source: Wikipedia]

Genes contained within the family: 16

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KLKB1 kallikrein B1 KLK3 4q35.2
KLK1 kallikrein 1 Klk6 19q13.33
KLK2 kallikrein related peptidase 2 19q13.33
KLK3 kallikrein related peptidase 3 APS PSA 19q13.33
KLK4 kallikrein related peptidase 4 PRSS17 EMSP, EMSP1, PSTS, KLK-L1 19q13.41
KLK5 kallikrein related peptidase 5 SCTE, KLK-L2 19q13.41
KLK6 kallikrein related peptidase 6 PRSS9, PRSS18 Bssp, Klk7, neurosin 19q13.3
KLK7 kallikrein related peptidase 7 PRSS6 SCCE 19q13.33
KLK8 kallikrein related peptidase 8 PRSS19 HNP, TADG14, neuropsin, ovasin 19q13
KLK9 kallikrein related peptidase 9 KLK-L3 19q13.33
KLK10 kallikrein related peptidase 10 PRSSL1 NES1 19q13.41
KLK11 kallikrein related peptidase 11 PRSS20 TLSP 19q13.41
KLK12 kallikrein related peptidase 12 KLK-L5 19q13.41
KLK13 kallikrein related peptidase 13 KLK-L4 19q13.41
KLK14 kallikrein related peptidase 14 KLK-L6 19q13.41
KLK15 kallikrein related peptidase 15 HSRNASPH, ACO, prostinogen 19q13.33