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Gene Family: Lamins (LMN)

Also known as : "Class V intermediate filaments", "Type V intermediate filaments"

Lamin: Nuclear lamins (not to be confused with laminins ), also known as Class V intermediate filaments, are fibrous proteins providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with membrane-associated proteins to form the nuclear lamina on the interior of the nuclear envelope. They are involved in the breakdown and reformation of the nuclear envelope during mitosis, as well as the positioning of nuclear pores. [Source: Wikipedia]

Genes contained within the family: 3

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
LMNA lamin A/C LMN1, CMD1A, LGMD1B, PRO1, LMNL1 HGPS, MADA 1q22
LMNB1 lamin B1 5q23.2
LMNB2 lamin B2 LMN2 19p13.3

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