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Gene Family: Keratins, type I

Also known as : "Keratins (acidic)", "Acidic keratins", "Type I keratins", "Type I intermediate filaments", "Type I cytokeratins"
A subset of : Keratins

Keratins: These proteins are the most diverse among IFs and constitute type I (acidic) and type II (basic) IF proteins. The many isoforms are divided in two groups: epithelial keratins (about 20) in epithelial cells (image to right) trichocytic keratins (about 13) (hair keratins), which make up hair, nails, horns and reptilian scales. Regardless of the group, keratins are either acidic or basic. Acidic and basic keratins bind each other to form acidic-basic heterodimers and these heterodimers then associate to make a keratin filament. [Source: Wikipedia. See also GO]

Genes contained within the family: 28

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KRT9 keratin 9 EPPK, K9, CK-9 17q21.2
KRT10 keratin 10 KPP K10, CK10 17q21.2
KRT12 keratin 12 K12 17q21.2
KRT13 keratin 13 K13, CK13, MGC3781, MGC161462 17q21.2
KRT14 keratin 14 EBS3, EBS4 17q21.2
KRT15 keratin 15 K15, CK15, K1CO 17q21.2
KRT16 keratin 16 NEPPK 17q21.2
KRT17 keratin 17 PCHC1 17q21.2
KRT18 keratin 18 12q13.13
KRT19 keratin 19 K19, CK19, K1CS, MGC15366 17q21.2
KRT20 keratin 20 CK20, K20, MGC35423 17q21.2
KRT23 keratin 23 K23, DKFZP434G032, HAIK1, CK23, MGC26158 17q21.2
KRT24 keratin 24 FLJ20261, MGC138169, MGC138173 17q21.2
KRT25 keratin 25 KRT25A 17q21.2
KRT26 keratin 26 KRT25B 17q21.2
KRT27 keratin 27 KRT25C 17q21.2
KRT28 keratin 28 KRT25D 17q21.2
KRT31 keratin 31 KRTHA1 Ha-1 17q21.2
KRT32 keratin 32 KRTHA2 Ha-2 17q21.2
KRT33A keratin 33A KRTHA3A Ha-3I, Krt1-3 17q21.2
KRT33B keratin 33B KRTHA3B Ha-3II 17q21.2
KRT34 keratin 34 KRTHA4 Ha-4 17q21.2
KRT35 keratin 35 KRTHA5 Ha-5 17q21.2
KRT36 keratin 36 KRTHA6 17q21.2
KRT37 keratin 37 KRTHA7 17q21.2
KRT38 keratin 38 KRTHA8 17q21.2
KRT39 keratin 39 KA35 17q21.2
KRT40 keratin 40 FLJ36600, KA36 17q21.2

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