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Gene Family: Interleukins (IL)

Interleukin: Interleukins are a group of cytokines (secreted proteins and signaling molecules ) that were first seen to be expressed by white blood cells ( leukocytes ). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice. [Source: Wikipedia]

Genes contained within the family: 43

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
IL1A interleukin 1 alpha IL1 IL1F1, IL-1A, IL1-ALPHA 2q14.1
IL1B interleukin 1 beta IL1F2, IL-1B, IL1-BETA 2q14.1
IL1F10 interleukin 1 family member 10 FKSG75, IL-1HY2, IL-1F10, IL1-theta, MGC11983, MGC119832, MGC119833 2q14.1
IL1RN interleukin 1 receptor antagonist IL1RA, ICIL-1RA, IL1F3, IRAP, IL-1RN, MGC10430 2q14.1
IL2 interleukin 2 IL-2, TCGF 4q27
IL3 interleukin 3 IL-3, MULTI-CSF, MCGF, MGC79398, MGC79399 5q31.1
IL4 interleukin 4 BSF1, IL-4, BCGF1, BCGF-1, MGC79402 5q31.1
IL5 interleukin 5 IL-5, EDF, TRF 5q31.1
IL6 interleukin 6 IFNB2 IL-6, BSF2, HGF, HSF 7p15.3
IL7 interleukin 7 IL-7 8q21.13
CXCL8 C-X-C motif chemokine ligand 8 IL8 SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1 4q13.3
IL9 interleukin 9 IL-9, HP40, P40 5q31.1
IL10 interleukin 10 CSIF, TGIF, IL10A, IL-10 1q32.1
IL11 interleukin 11 IL-11, AGIF 19q13.42
IL12A interleukin 12A NKSF1 CLMF, IL-12A, p35, NFSK 3q25.33
IL12B interleukin 12B NKSF2 CLMF, IL-12B, NKSF, CLMF2 5q33.3
IL13 interleukin 13 P600, IL-13, ALRH, BHR1, MGC116786, MGC116788, MGC116789 5q31.1
IL15 interleukin 15 IL-15, MGC9721 4q31.21
IL16 interleukin 16 LCF, IL-16, prIL-16, HsT19289, FLJ42735, FLJ16806 15q25.1
IL17A interleukin 17A CTLA8, IL17 IL-17A, IL-17 6p12.2
IL17B interleukin 17B IL-17B, ZCYTO7, IL-20, MGC138900, MGC138901, NIRF 5q32
IL17C interleukin 17C IL-17C, CX2, IL-21, MGC126884, MGC138401 16q24.2
IL17D interleukin 17D IL-22, IL-27, IL-17D, IL27, FLJ30846 13q12.11
IL17F interleukin 17F IL-17F, ML-1, ML1 6p12.2
IL18 interleukin 18 IGIF, IL1F4, IL-1g, IL-18 11q23.1
IL19 interleukin 19 IL-19, MDA1, ZMDA1, IL-10C, NG.1 1q32.1
IL20 interleukin 20 ZCYTO10, IL10D, IL-20 1q32.1
IL21 interleukin 21 Za11, IL-21 4q27
IL22 interleukin 22 ILTIF, IL-21, zcyto18, IL-TIF, IL-D110, TIFa, TIFIL-23, IL-22, MGC79382, MGC79384 12q15
IL23A interleukin 23 subunit alpha SGRF, IL23P19, IL-23, IL-23A, P19 12q13.3
IL24 interleukin 24 ST16 mda-7, IL10B, Mob-5, C49A, FISP, IL-24 1q32.1
IL25 interleukin 25 IL17E IL-25, IL-17E 14q11.2
IL26 interleukin 26 AK155, IL-26 12q15
IL27 interleukin 27 IL30 IL-27, p28, IL27p28, IL-27A, IL27A, MGC71873 16p12.1-p11.2
IL31 interleukin 31 IL-31 12q24.31
IL32 interleukin 32 NK4, TAIF, TAIFb, TAIFd 16p13.3
IL33 interleukin 33 C9orf26 DVS27, DKFZp586H0523, NF-HEV, IL1F11 9p24.1
IL34 interleukin 34 C16orf77 MGC34647, IL-34 16q22.1
IL36A interleukin 36 alpha IL1F6 FIL1, FIL1E, IL-1F6, IL1(EPSILON), MGC129553, MGC129552 2q14.1
IL36B interleukin 36 beta IL1F8 FIL1, IL-1H2, IL-1F8, FILI-(ETA), IL1-ETA, IL1H2, MGC126880, MGC126882 2q14.1
IL36G interleukin 36 gamma IL1F9 IL-1H1, IL-1RP2, IL-1F9, IL1H1, IL1E 2q14.1
IL36RN interleukin 36 receptor antagonist IL1F5 FIL1, FIL1(DELTA), FIL1D, IL1HY1, IL1RP3, IL1L1, IL-1F5, IL36RA, MGC29840 2q14.1
IL37 interleukin 37 IL1F7 FIL1, FIL1Z, FIL1(ZETA), IL-1H4, IL-1RP1, IL-1F7 2q14.1

Comments

Note that IL1RN and IL36RN are included here because they are part of the interleukin family in terms of homology. However, the products of these genes are not functional interleukins, but bind to interleukin receptors without inducing a biological response.

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