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Gene Family: Histocompatibility complex (HLA)

Also known as : "Major histocompatibility complex", "MHC", "Human leukocyte antigens"

Major histocompatibility complex: The major histocompatibility complex ( MHC ) is a set of cell surface molecules encoded by a large gene family in all vertebrates. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or body cells. MHC determines compatibility of donors for organ transplant as well as one's susceptibility to an autoimmune disease via crossreacting immunization. [Source: Wikipedia]

Genes contained within the family: 44

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HLA-A major histocompatibility complex, class I, A 6p22.1
HLA-B major histocompatibility complex, class I, B AS 6p21.33
HLA-C major histocompatibility complex, class I, C HLA-JY3, D6S204, PSORS1 6p21.33
HLA-DMA major histocompatibility complex, class II, DM alpha D6S222E, RING6 6p21.32
HLA-DMB major histocompatibility complex, class II, DM beta D6S221E, RING7 6p21.32
HLA-DOA major histocompatibility complex, class II, DO alpha HLA-DZA, HLA-DNA HLA-D0-alpha 6p21.32
HLA-DOB major histocompatibility complex, class II, DO beta 6p21.32
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 HLA-DP1A 6p21.32
HLA-DPA2 major histocompatibility complex, class II, DP alpha 2 (pseudogene) HLA-DP2A 6p21.32
HLA-DPA3 major histocompatibility complex, class II, DP alpha 3 (pseudogene) 6p21.32
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 HLA-DP1B 6p21.32
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) HLA-DP2B DP2B, DPB2 6p21.32
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 HLA-DQA CELIAC1 6p21.32
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 HLA-DXA 6p21.32
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 HLA-DQB IDDM1, CELIAC1 6p21.32
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 HLA-DXB 6p21.32
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 HLA-DVB D6S205, D6S205E, DVB, DQB3 6p21.3
HLA-DRA major histocompatibility complex, class II, DR alpha HLA-DRA1 6p21.32
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 HLA-DR1B 6p21.32
HLA-DRB2 major histocompatibility complex, class II, DR beta 2 (pseudogene) HLA-DR2B 6p21.3 alternate reference locus
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 HLA-DR3B 6p21.3 alternate reference locus
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 HLA-DR4B 6p21.3 alternate reference locus
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 6p21.32
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene) 6p21.32
HLA-DRB7 major histocompatibility complex, class II, DR beta 7 (pseudogene) 6p21.3 alternate reference locus
HLA-DRB8 major histocompatibility complex, class II, DR beta 8 (pseudogene) 6p21.3 alternate reference locus
HLA-DRB9 major histocompatibility complex, class II, DR beta 9 (pseudogene) HLA-DRB1L, HLA-DR1BL D6S206, D6S206E 6p21.32
HLA-E major histocompatibility complex, class I, E 6p22.1
HLA-F major histocompatibility complex, class I, F 6p22.1
HLA-G major histocompatibility complex, class I, G 6p22.1
HLA-H major histocompatibility complex, class I, H (pseudogene) 6p22.1
HLA-J major histocompatibility complex, class I, J (pseudogene) HLA-CDA12, D6S203 CDA12, HLA-59 6p22.1
HLA-K major histocompatibility complex, class I, K (pseudogene) HLAK, HLA70 HLA-70 6p22.1
HLA-L major histocompatibility complex, class I, L (pseudogene) HLA92, HLAL HLA-92 6p22.1
HLA-N major histocompatibility complex, class I, N (pseudogene) HLA-30 6p22.1
HLA-P major histocompatibility complex, class I, P (pseudogene) C6orf101, HLA-90 dJ377H14.3 6p22.1
HLA-S major histocompatibility complex, class I, S (pseudogene) HLA-17 6p21.33
HLA-T major histocompatibility complex, class I, T (pseudogene) HLA-16 6p22.1
HLA-U major histocompatibility complex, class I, U (pseudogene) HLA-21 Em:AB023056.13 6p22.1
HLA-V major histocompatibility complex, class I, V (pseudogene) HLA-75 dJ377H14.4 6p22.1
HLA-W major histocompatibility complex, class I, W (pseudogene) HLA-80 6p22.1
HLA-X major histocompatibility complex, class I, X (pseudogene) 6p21.3
HLA-Y major histocompatibility complex, class I, Y (pseudogene) HLA-BEL/COQ/DEL 6p21.33
HLA-Z major histocompatibility complex, class I, Z (pseudogene) HLA-Z1 6p21.32

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