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Gene Family: Heat shock 90kDa proteins (HSP90)

A subset of : Heat shock proteins

Hsp90: Hsp90 ( heat shock protein 90 ) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why Hsp90 inhibitors are investigated as anti-cancer drugs. Heat shock proteins, as a class, are among the most highly expressed cellular proteins across all species. As their name implies, heat shock proteins protect cells when stressed by elevated temperatures. They account for 1-2% of total protein in unstressed cells. However, when cells are heated, the fraction of heat shock proteins increases to 4-€“6% of cellular proteins. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
HSP90AA1 heat shock protein 90 alpha family class A member 1 HSPC1, HSPCA Hsp89, Hsp90, FLJ31884, HSP90N 14q32.31
HSP90AA3P heat shock protein 90 alpha family class A member 3, pseudogene HSPCAL1 1q23.1
HSP90AB1 heat shock protein 90 alpha family class B member 1 HSPC2, HSPCB 6p21.1
HSP90B1 heat shock protein 90 beta family member 1 TRA1 GP96, GRP94 12q23.3
TRAP1 TNF receptor associated protein 1 HSP75, HSP90L 16p13.3