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Gene Family: General transcription factors (GTF)

General transcription factor: General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites on DNA to activate transcription. GTFs, RNA polymerase, and the mediator multiple protein complex constitute the basic transcriptional apparatus. GTFs are also intimately involved in the process of gene regulation, and most are required for life. [Source: Wikipedia]

Genes contained within the family: 25

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GTF2A1 general transcription factor IIA subunit 1 TFIIA 14q31.1
GTF2A2 general transcription factor IIA subunit 2 TFIIA, HsT18745 15q22.2
GTF2B general transcription factor IIB TFIIB 1p22.2
TBP TATA-box binding protein SCA17, GTF2D1 TFIID 6q27
GTF2E1 general transcription factor IIE subunit 1 TFIIE-A, FE 3q13.33
GTF2E2 general transcription factor IIE subunit 2 TFIIE-B, FE, TF2E2 8p12
GTF2F1 general transcription factor IIF subunit 1 TFIIF, BTF4, RAP74, TF2F1 19p13.3
GTF2F2 general transcription factor IIF subunit 2 TFIIF, BTF4, RAP30 13q14.12-q14.13
GTF2H1 general transcription factor IIH subunit 1 BTF2, P62, TFIIH 11p15.1
GTF2H2 general transcription factor IIH subunit 2 BTF2, TFIIH, BTF2P44, T-BTF2P44, p44 5q13.2
GTF2H3 general transcription factor IIH subunit 3 BTF2, TFIIH, P34 12q24.31
GTF2H4 general transcription factor IIH subunit 4 TFB2, TFIIH, P52 6p21.33
GTF2H5 general transcription factor IIH subunit 5 C6orf175, TTD FLJ30544, bA120J8.2, TTD-A, TFB5, TFIIH, TTDA 6q25.3
ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit XPD MAG, EM9, MGC102762, MGC126218, MGC126219, TFIIH 19q13.32
ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit XPB, BTF2, RAD25, TFIIH, GTF2H 2q14.3
GTF2I general transcription factor IIi WBSCR6 TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291 7q11.23
TCEA1 transcription elongation factor A1 TCEA, GTF2S SII, TF2S, TFIIS 8q11.23
GTF3A general transcription factor IIIA TFIIIA, AP2 13q12.2
BRF1 BRF1, RNA polymerase III transcription initiation factor subunit GTF3B, TAF3B2, TAF3C TFIIIB90, BRF, hBRF 14q32.33
GTF3C1 general transcription factor IIIC subunit 1 TFIIIC220 16p12.1
GTF3C2 general transcription factor IIIC subunit 2 KIAA0011, TFIIIC110 2p23.3
GTF3C3 general transcription factor IIIC subunit 3 TFiiiC2-102, TFIIIC102 2q33.1
GTF3C4 general transcription factor IIIC subunit 4 TFIIIC90, KAT12 9q34.13
GTF3C5 general transcription factor IIIC subunit 5 TFiiiC2-63, TFIIIC63, TFIIICepsilon 9q34.13
GTF3C6 general transcription factor IIIC subunit 6 C6orf51 bA397G5.3, TFIIIC35 6q21