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Gene Family: Gamma-glutamyltransferases (GGT)

Gamma-glutamyl transferase: Gamma-glutamyl transferase or gamma-glutamyl transpeptidase ( EC 2.3.2.2 ) is an enzyme that transfers gamma-glutamyl functional groups. It is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker. GGT catalyzes the transfer of the gamma-glutamyl moiety of glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate ). GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione and drug and xenobiotic detoxification. [Source: Wikipedia]

Genes contained within the family: 13

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GGTLC1 gamma-glutamyltransferase light chain 1 GGTLA4, GGTLA3 dJ831C21.2, dJ831C21.1 20p11.21
GGTLC2 gamma-glutamyltransferase light chain 2 GGTL4 22q11.22
GGTLC3 gamma-glutamyltransferase light chain 3 22q11.21
GGTLC4P gamma-glutamyltransferase light chain 4 pseudogene 22q11.23
GGTLC5P gamma-glutamyltransferase light chain 5 pseudogene 22q11.21
GGT1 gamma-glutamyltransferase 1 GGT D22S672, D22S732, CD224 22q11.23
GGT2 gamma-glutamyltransferase 2 GGT 22q11.21
GGT3P gamma-glutamyltransferase 3 pseudogene GGT3 22q11.21
GGT4P gamma-glutamyltransferase 4 pseudogene 13q11
GGT5 gamma-glutamyltransferase 5 GGTLA1 GGT-REL 22q11.23
GGT6 gamma-glutamyltransferase 6 FLJ90165 17p13.2
GGT7 gamma-glutamyltransferase 7 GGTL5, GGTL3 D20S101, dJ18C9.2 20q11.22
GGT8P gamma-glutamyltransferase 8 pseudogene GGT1P1 FLJ31276 2p11.2

Publications

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