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Gene Family: Gamma-aminobutyric acid type A receptor subunits (GABR)

Also known as : "GABA(A) receptors", "GABA ARs", "GABA A receptors", "Gamma-aminobutyric acid (GABA) A receptors"

GABAA receptor: The GABA A receptor (GABA AR) is an ionotropic receptor and ligand-gated ion channel. Its endogenous ligand is gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Upon activation, the GABA A receptor selectively conducts Cl-ˆ’ through its pore, resulting in hyperpolarization of the neuron. This causes an inhibitory effect on neurotransmission by diminishing the chance of a successful action potential occurring. The reversal potential of the GABA A-mediated IPSP in normal solution is -ˆ’70 mV, contrasting the GABA B IPSP. [Source: Wikipedia]

Genes contained within the family: 19

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GABRA1 gamma-aminobutyric acid type A receptor alpha1 subunit EJM5 5q34
GABRA2 gamma-aminobutyric acid type A receptor alpha2 subunit 4p12
GABRA3 gamma-aminobutyric acid type A receptor alpha3 subunit Xq28
GABRA4 gamma-aminobutyric acid type A receptor alpha4 subunit 4p12
GABRA5 gamma-aminobutyric acid type A receptor alpha5 subunit 15q12
GABRA6 gamma-aminobutyric acid type A receptor alpha6 subunit 5q34
GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 4p12
GABRB2 gamma-aminobutyric acid type A receptor beta2 subunit 5q34
GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 15q12
GABRD gamma-aminobutyric acid type A receptor delta subunit 1p36.33
GABRE gamma-aminobutyric acid type A receptor epsilon subunit Xq28
GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 4p12
GABRG2 gamma-aminobutyric acid type A receptor gamma2 subunit 5q34
GABRG3 gamma-aminobutyric acid type A receptor gamma3 subunit 15q12
GABRP gamma-aminobutyric acid type A receptor pi subunit 5q35.1
GABRQ gamma-aminobutyric acid type A receptor theta subunit THETA Xq28
GABRR1 gamma-aminobutyric acid type A receptor rho1 subunit 6q15
GABRR2 gamma-aminobutyric acid type A receptor rho2 subunit 6q15
GABRR3 gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) 3q11.2