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Gene Family: Fermitins (FERMT)

Also known as : "Kinderlins", "Kindlins"

Fermitins: The [fermitin or] kindlin family of proteins each contain a bipartite FERM domain comprising four subdomains F0, F1, F2, and F3 that show homology with the FERM head (H) domain of the cytoskeletal Talin protein. Kindlins have been linked to Kindler syndrome, leukocyte adhesion deficiency, cancer and other acquired human diseases. They are essential in the organisation of focal adhesions that mediate cell-extracellular matrix junctions and are involved in other cellular compartments that control cell-cell contacts and nucleus functioning. Therefore they are responsible for cell to cell crosstalk via cell-cell contacts and integrin mediated cell adhesion through focal adhesion proteins and as specialised adhesion structures of hematopoietic cells they are also present in podosome's F actin surrounding ring structure. [Source: Wikipedia]

Genes contained within the family: 3

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
FERMT1 fermitin family member 1 C20orf42 FLJ20116, URP1, KIND1, UNC112A 20p12.3
FERMT2 fermitin family member 2 PLEKHC1 mig-2, KIND2, UNC112B 14q22.1
FERMT3 fermitin family member 3 URP2, KIND3, MIG2B, MGC10966, MIG-2, UNC112C 11q13.1