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Gene Family: Dyneins, cytoplasmic (DYN)

A subset of : Dyneins

Cytoplasmic dyneins: Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), contains approximately twelve polypeptide subunits: two identical "heavy chains", 520 kDa in mass, which contain the ATPase activity and are thus responsible for generating movement along the microtubule; two 74 kDa intermediate chains which are believed to anchor the dynein to its cargo; four 53–59 kDa intermediate chains; and several light chains which are less understood. [Source: Wikipedia]

Genes contained within the family: 13

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DYNC1H1 dynein cytoplasmic 1 heavy chain 1 DNECL, DNCL, DNCH1 Dnchc1, HL-3, p22, DHC1, CMT2O 14q32.31
DYNC1I1 dynein cytoplasmic 1 intermediate chain 1 DNCI1 DNCIC1 7q21.3
DYNC1I2 dynein cytoplasmic 1 intermediate chain 2 DNCI2 DIC74 2q31.1
DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 DNCLI1 3p22.3
DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 DNCLI2 16q22.1
DYNC2H1 dynein cytoplasmic 2 heavy chain 1 DNCH2 hdhc11, DHC2, DHC1b, DYH1B 11q22.3
DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 D2LIC, LIC3, CGI-60, DKFZP564A033 2p21
DYNLL1 dynein light chain LC8-type 1 DNCL1 hdlc1, DLC1, PIN, LC8, DLC8 12q24.31
DYNLL2 dynein light chain LC8-type 2 MGC17810, Dlc2, DNCL1B, RSPH22 17q22
DYNLRB1 dynein light chain roadblock-type 1 DNCL2A DNLC2A, ROBLD1 20q11.22
DYNLRB2 dynein light chain roadblock-type 2 DNCL2B DNLC2B, ROBLD2 16q23.2
DYNLT1 dynein light chain Tctex-type 1 TCTEL1 6q25.3
DYNLT3 dynein light chain Tctex-type 3 TCTE1L TCTEX1L Xp11.4

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