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Gene Family: Dyneins, axonemal (DNA)

Also known as : "Axonemal dyneins"
A subset of : Dyneins

Axonemal dyneins: Axonemal dyneins come in multiple forms that contain either one, two or three non-identical heavy chains (depending upon the organism and location in the cilium). Each heavy chain has a globular motor domain with a doughnut-shaped structure believed to resemble that of other AAA proteins, a coiled coil "stalk" that binds to the microtubule, and an extended tail (or "stem") that attaches to a neighboring microtubule of the same axoneme. Each dynein molecule thus forms a cross-bridge between two adjacent microtubules of the ciliary axoneme. [Source: Wikipedia]

Genes contained within the family: 17

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DNAH1 dynein axonemal heavy chain 1 XLHSRF-1, DNAHC1, HDHC7, HL-11, HL11 3p21.1
DNAH2 dynein axonemal heavy chain 2 DNHD3 KIAA1503, FLJ46675 17p13.1
DNAH3 dynein axonemal heavy chain 3 Dnahc3b, DLP3, Hsadhc3, DKFZp434N074 16p12.3
DNAH5 dynein axonemal heavy chain 5 Dnahc5, HL1, PCD, CILD3, KTGNR 5p15.2
DNAH6 dynein axonemal heavy chain 6 DNHL1 Dnahc6, HL-2, FLJ37357 2p11.2
DNAH7 dynein axonemal heavy chain 7 KIAA0944 2q32.3
DNAH8 dynein axonemal heavy chain 8 hdhc9 6p21.2
DNAH9 dynein axonemal heavy chain 9 DNAH17L Dnahc9, KIAA0357, HL20, HL-20, DNAL1, DYH9 17p12
DNAH10 dynein axonemal heavy chain 10 FLJ43808 12q24.31
DNAH11 dynein axonemal heavy chain 11 Dnahc11, DPL11, CILD7, DNAHC11, DNAHBL, DNHBL 7p15.3
DNAH12 dynein axonemal heavy chain 12 DNHD2, DNAH12L, DNAH7L DLP12, Dnahc3, HL-19, hdhc3, DHC3, FLJ40427, FLJ44290 3p14.3
DNAH14 dynein axonemal heavy chain 14 C1orf67 Dnahc14, HL-18, HL18, DKFZp781B1548, MGC27277 1q42.12
DNAH17 dynein axonemal heavy chain 17 DNAHL1 DNEL2, FLJ40457 17q25.3
DNAI1 dynein axonemal intermediate chain 1 DIC1, PCD, CILD1 9p13.3
DNAI2 dynein axonemal intermediate chain 2 CILD9, DIC2 17q25.1
DNALI1 dynein axonemal light intermediate chain 1 P28, hp28, dJ423B22.5 1p34.3
DNAL4 dynein axonemal light chain 4 dJ327J16, PIG27 22q13.1

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