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Gene Family: Forkhead boxes (FOX)

FOX proteins: FOX (Forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development. FOX proteins also have pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes. The defining feature of FOX proteins is the forkhead box, a sequence of 80 to 100 amino acids forming a motif that binds to DNA. This forkhead motif is also known as the winged helix due to the butterfly-like appearance of the loops in the protein structure of the domain. Forkhead genes are a subgroup of the helix-turn-helix class of proteins. [Source: Wikipedia]

Genes contained within the family: 43

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
FOXA1 forkhead box A1 HNF3A 14q21.1
FOXA2 forkhead box A2 HNF3B 20p11.21
FOXA3 forkhead box A3 HNF3G 19q13.32
FOXB1 forkhead box B1 HFKH-5, FKH5 15q22.2
FOXB2 forkhead box B2 bA159H20.4 9q21.2
FOXC1 forkhead box C1 FKHL7, IRID1 FREAC3, ARA, IGDA, IHG1 6p25.3
FOXC2 forkhead box C2 FKHL14 MFH-1 16q24.1
FOXD1 forkhead box D1 FKHL8 FREAC4 5q13.2
FOXD2 forkhead box D2 FKHL17 FREAC9 1p33
FOXD3 forkhead box D3 Genesis, HFH2 1p31.3
FOXD4 forkhead box D4 FKHL9 FREAC5, FOXD4a 9p24.3
FOXE1 forkhead box E1 FKHL15, TITF2, FOXE2 TTF-2, HFKH4 9q22.33
FOXE3 forkhead box E3 FKHL12 FREAC8 1p33
FOXF1 forkhead box F1 FKHL5 FREAC1 16q24.1
FOXF2 forkhead box F2 FKHL6 FREAC2 6p25.3
FOXG1 forkhead box G1 FKHL2, FOXG1B, FKHL4, FKH2, FKHL1, FOXG1C, FKHL3, FOXG1A HFK2, QIN, BF1, HFK1, HFK3, HBF-3 14q12
FOXH1 forkhead box H1 FAST1 8q24.3
FOXI1 forkhead box I1 FKHL10 FREAC6 5q35.1
FOXI2 forkhead box I2 FLJ46831 10q26.2
FOXJ1 forkhead box J1 FKHL13 HFH-4, HFH4 17q25.1
FOXJ2 forkhead box J2 FHX 12p13.31
FOXJ3 forkhead box J3 KIAA1041 1p34.2
FOXK1 forkhead box K1 IMAGE:5164497 7p22.1
FOXK2 forkhead box K2 ILF, ILF1 17q25.3
FOXL1 forkhead box L1 FKHL11 FREAC7, FKH6 16q24.1
FOXL2 forkhead box L2 BPES BPES1 3q22.3
FOXM1 forkhead box M1 FKHL16 HFH-11, trident, HNF-3, INS-1, MPP2, MPHOSPH2, TGT3 12p13.33
FOXN1 forkhead box N1 WHN, RONU FKHL20 17q11.2
FOXN2 forkhead box N2 HTLF 2p16.3
FOXN3 forkhead box N3 C14orf116, CHES1 14q31.3-q32.11
FOXN4 forkhead box N4 12q24.11
FOXO1 forkhead box O1 FKHR, FOXO1A FKH1 13q14.11
FOXO3 forkhead box O3 FKHRL1, FOXO3A AF6q21, FOXO2 6q21
FOXO4 forkhead box O4 MLLT7 AFX1 Xq13.1
FOXO6 forkhead box O6 1p34.2
FOXP1 forkhead box P1 QRF1, 12CC4, HSPC215, hFKH1B 3p13
FOXP2 forkhead box P2 TNRC10, SPCH1 CAGH44 7q31.1
FOXP4 forkhead box P4 FLJ40908 6p21.1
FOXQ1 forkhead box Q1 HFH1 6p25.3
FOXR1 forkhead box R1 DLNB13, FOXN5 11q23.3
FOXR2 forkhead box R2 MGC21658, FOXN6 Xp11.21
FOXS1 forkhead box S1 FKHL18 FREAC10 20q11.21

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