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Gene Family: DEAD-box helicases (DDX)

Also known as : "DEAD box polypeptides"
A subset of : RNA helicases

DEAD box: DEAD box proteins are involved in an assortment of metabolic processes that typically involve RNAs, but in some cases also other nucleic acids. They are highly conserved in nine motifs and can be found in both prokaryotes and eukaryotes, but not all. Many organisms, including humans, contain DEAD-box helicases, which are involved in RNA metabolism. [Source: Wikipedia]

Genes contained within the family: 42

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DDX1 DEAD-box helicase 1 DBP-RB 2p24.3
EIF4A1 eukaryotic translation initiation factor 4A1 EIF4A DDX2A, EIF-4A 17p13.1
EIF4A2 eukaryotic translation initiation factor 4A2 EIF4F BM-010, EIF4A, DDX2B 3q27.3
DDX3X DEAD-box helicase 3, X-linked DDX3 DBX, HLP2, DDX14 Xp11.4
DDX3Y DEAD-box helicase 3, Y-linked DBY Yq11.221
DDX4 DEAD-box helicase 4 VASA 5q11.2
DDX5 DEAD-box helicase 5 HLR1, G17P1 p68 17q23.3
DDX6 DEAD-box helicase 6 HLR2 RCK 11q23.3
DDX10 DEAD-box helicase 10 HRH-J8 11q22.3
DDX11 DEAD/H-box helicase 11 CHLR1, KRG2, CHL1, ChlR1, WABS 12p11.21
DDX12P DEAD/H-box helicase 12, pseudogene DDX12 CHLR2 12p13.31
DDX17 DEAD-box helicase 17 P72 22q13.1
DDX18 DEAD-box helicase 18 MrDb 2q14.1
DDX19A DEAD-box helicase 19A DDX19L FLJ11126 16q22.1
DDX19B DEAD-box helicase 19B DDX19 DBP5 16q22.1
DDX20 DEAD-box helicase 20 DP103, GEMIN3 1p13.2
DDX21 DExD-box helicase 21 RH-II/GU, GURDB 10q22.1
DDX23 DEAD-box helicase 23 prp28, U5-100K, PRPF28, SNRNP100 12q13.12
DDX24 DEAD-box helicase 24 14q32.12
DDX25 DEAD-box helicase 25 GRTH 11q24.2
DDX27 DEAD-box helicase 27 dJ686N3.1, DRS1 20q13.13
DDX28 DEAD-box helicase 28 MDDX28, FLJ11282 16q22.1
DDX31 DEAD-box helicase 31 FLJ13633, FLJ23349, FLJ14578, PPP1R25 9q34.13
DDX39A DExD-box helicase 39A DDX39 DDXL, BAT1L, URH49 19p13.12
DDX39B DExD-box helicase 39B BAT1 D6S81E, UAP56 6p21.33
DDX41 DEAD-box helicase 41 ABS, MGC8828 5q35.3
DDX42 DEAD-box helicase 42 RNAHP, RHELP, SF3b125, SF3B8 17q23.3
DDX43 DEAD-box helicase 43 HAGE, DKFZp434H2114, CT13 6q13
DDX46 DEAD-box helicase 46 KIAA0801, FLJ25329, PRPF5, Prp5 5q31.1
DDX47 DEAD-box helicase 47 DKFZp564O176, FLJ30012, HQ0256, RRP3 12p13.1
EIF4A3 eukaryotic translation initiation factor 4A3 DDX48 KIAA0111, EIF4AIII 17q25.3
DDX49 DEAD-box helicase 49 FLJ10432 19p13.11
DDX50 DExD-box helicase 50 GU2, MGC3199, GUB, RH-II/GuB 10q22.1
DDX51 DEAD-box helicase 51 12q24.33
DDX52 DExD-box helicase 52 ROK1 17q12
DDX53 DEAD-box helicase 53 CAGE, CT26 Xp22.11
DDX54 DEAD-box helicase 54 MGC2835, APR-5, DP97 12q24.13
DDX55 DEAD-box helicase 55 KIAA1595 12q24.31
DDX56 DEAD-box helicase 56 NOH61 7p13
DDX58 DExD/H-box helicase 58 RIG-I, FLJ13599, DKFZp434J1111 9p21.1
DDX59 DEAD-box helicase 59 DKFZP564B1023, ZNHIT5 1q32.1
DDX60 DExD/H-box helicase 60 FLJ20035 4q32.3

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