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Gene Family: Cyclin dependent kinases (CDK)

Cyclin-dependent kinase: Cyclin-dependent kinases (CDKs) are a family of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase. CDKs phosphorylate their substrates on serines and threonines, so they are serine-threonine kinases. The consensus sequence for the phosphorylation site in the amino acid sequence of a CDK substrate is PX, where S/T* is the phosphorylated serine or threonine, P is proline, X is any amino acid, K is lysine, and R is arginine [Source: Wikipedia]

Genes contained within the family: 26

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CDKL1 cyclin dependent kinase like 1 KKIALRE 14q21.3
CDKL2 cyclin dependent kinase like 2 P56, KKIAMRE 4q21.1
CDKL3 cyclin dependent kinase like 3 NKIAMRE 5q31.1
CDKL4 cyclin dependent kinase like 4 2p22.1
CDKL5 cyclin dependent kinase like 5 STK9 EIEE2, CFAP247 Xp22.13
CDK1 cyclin dependent kinase 1 CDC2 CDC28A 10q21.2
CDK2 cyclin dependent kinase 2 12q13.2
CDK3 cyclin dependent kinase 3 17q25.1
CDK4 cyclin dependent kinase 4 PSK-J3 12q14.1
CDK5 cyclin dependent kinase 5 PSSALRE 7q36.1
CDK6 cyclin dependent kinase 6 PLSTIRE 7q21.2
CDK7 cyclin dependent kinase 7 CAK1, CDKN7, MO15, STK1, CAK 5q13.2
CDK8 cyclin dependent kinase 8 K35 13q12.13
CDK9 cyclin dependent kinase 9 CDC2L4 PITALRE, C-2k, TAK 9q34.11
CDK10 cyclin dependent kinase 10 PISSLRE 16q24.3
CDK11A cyclin dependent kinase 11A CDC2L3, CDC2L2 PITSLRE, CDK11-p110, CDK11-p58, CDK11-p46, p58GTA 1p36.33
CDK11B cyclin dependent kinase 11B CDC2L1 CDK11-p110, CDK11-p58, CDK11-p46 1p36.33
CDK12 cyclin dependent kinase 12 CRKRS CRK7, CRKR, KIAA0904 17q12
CDK13 cyclin dependent kinase 13 CDC2L5 CHED, CDC2L, KIAA1791 7p14.1
CDK14 cyclin dependent kinase 14 PFTK1 PFTAIRE1 7q21.13
CDK15 cyclin dependent kinase 15 ALS2CR7, PFTK2 PFTAIRE2 2q33.1
CDK16 cyclin dependent kinase 16 PCTK1 PCTAIRE, PCTAIRE1, PCTGAIRE, FLJ16665 Xp11.3
CDK17 cyclin dependent kinase 17 PCTK2 PCTAIRE2 12q23.1
CDK18 cyclin dependent kinase 18 PCTK3 PCTAIRE3 1q32.1
CDK19 cyclin dependent kinase 19 CDK11, CDC2L6 KIAA1028, bA346C16.3 6q21
CDK20 cyclin dependent kinase 20 CCRK p42 9q22.1

Publications

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