Skip to Navigation

Gene Family: Complement system

Complement system: The complement system helps or "€œcomplements"€ the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system. The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins. [Source: Wikipedia]

Genes contained within the family: 36

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CD46 CD46 molecule MIC10, MCP TRA2.10, MGC26544, TLX 1q32.2
CD59 CD59 molecule (CD59 blood group) MIC11, MIN1, MSK21, MIN2, MIN3 16.3A5, EJ16, EJ30, EL32, G344, p18-20 11p13
CFB complement factor B BFD, BF H2-Bf 6p21.33
CFD complement factor D DF, PFD ADN 19p13.3
CFH complement factor H HF, HF1, HF2 HUS, FHL1, ARMS1, ARMD4 1q31.3
CFHR1 complement factor H related 1 HFL1, CFHL1, CFHR1P, HFL2, CFHL1P H36-1, FHR1, CFHL, H36-2 1q31.3
CFHR2 complement factor H related 2 HFL3, CFHL2 FHR2 1q31.3
CFHR3 complement factor H related 3 CFHL3 FHR-3, HLF4, FHR3, DOWN16 1q31.3
CFHR4 complement factor H related 4 CFHL4 FHR-4, FHR4 1q31.3
CFHR5 complement factor H related 5 CFHL5 FHR5, FHR-5 1q31.3
CFI complement factor I IF FI, C3b-INA, KAF 4q25
CFP complement factor properdin PFC Xp11.23
CR1 complement C3b/C4b receptor 1 (Knops blood group) CD35, KN 1q32.2
CR1L complement C3b/C4b receptor 1 like 1q32.2
CR2 complement C3d receptor 2 CD21, C3DR 1q32.2
C1QA complement C1q A chain 1p36.12
C1QB complement C1q B chain 1p36.12
C1QC complement C1q C chain C1QG 1p36.12
C1R complement C1r 12p13.31
C1S complement C1s 12p13.31
C2 complement C2 6p21.33
C3 complement C3 CPAMD1, ARMD9, C3a, C3b 19p13.3
C3AR1 complement C3a receptor 1 C3AR, AZ3B 12p13.31
C4A complement C4A (Rodgers blood group) CPAMD2, C4S, CO4, C4, C4A3, C4A2, C4A4, C4A6, C4B, RG 6p21.33
C4B complement C4B (Chido blood group) CPAMD3, C4F, CO4, C4B1, C4B3, CH 6p21.33
C5 complement C5 CPAMD4, C5a, C5b 9q33.2
C5AR1 complement C5a receptor 1 C5R1 C5A, C5AR, CD88 19q13.32
C6 complement C6 5p13.1
C7 complement C7 5p13.1
C8A complement C8 alpha chain 1p32.2
C8B complement C8 beta chain 1p32.2
C8G complement C8 gamma chain 9q34.3
C9 complement C9 5p13.1
ITGAM integrin subunit alpha M CR3A, CD11B MAC-1, CD11b 16p11.2
ITGAX integrin subunit alpha X CD11C CD11c 16p11.2
ITGB2 integrin subunit beta 2 CD18, MFI7 LFA-1, MAC-1 21q22.3

Specialist advisors