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Gene Family: Collectins (COLEC)

Also known as : "collagen-containing C-type lectins"

Collectin: Collectins (collagen-containing C-type lectins) are a part of the innate immune system. They form a family of collagenous Ca 2+ -dependent defense lectins, which are found in animals. Collectins are soluble pattern recognition receptors (PRRs). Their function is to bind to oligosaccharide structure or lipids which are on the surface of microorganisms. Like other PRRs they bind pathogen-associated molecular patterns (PAMPs) and also danger-associated molecular patterns (DAMPs) of oligosaccharide origin. Binding of collectins to microorganisms may trigger elimination of microorganisms by aggregation, complement activation, opsonization, activation of phagocytosis or inhibition of microbial growth. Other functions of collectins are modulation of inflammatory, allergic responses, adaptive immune system and clearance of apoptotic cells. [Source: Wikipedia]

Genes contained within the family: 10

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MBL2 mannose binding lectin 2 MBL COLEC1 10q21.1
MBL3P mannose-binding lectin family member 3, pseudogene COLEC2 MBL 10q22.3
MBL1P mannose binding lectin 1, pseudogene MBL1P1 COLEC3P 10q22.3
SFTPA1 surfactant protein A1 SFTP1 COLEC4, SP-A1, SP-A 10q22.3
SFTPA2 surfactant protein A2 COLEC5, SP-A2 10q22.3
SFTPA3P surfactant protein A3, pseudogene SFTPP1, SFTPAP1 COLEC6 10q22.3
SFTPD surfactant protein D SFTP4 SP-D, COLEC7 10q22.3
COLEC10 collectin subfamily member 10 CL-L1 8q24.12
COLEC11 collectin subfamily member 11 MGC3279, CL-K1 2p25.3
COLEC12 collectin subfamily member 12 SRCL, CL-P1, SCARA4 18p11.32

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