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Gene Family: Chemokine ligands (CCL)

Also known as : "Chemokines"

Chemokine: Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemo tactic cyto kines. Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. However, these proteins have historically been known under several other names including the SIS family of cytokines, SIG family of cytokines, SCY family of cytokines, Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro- inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria, but none have been described for other invertebrates. Chemokines have been classified into four main subfamilies : CXC, CC, CX3C and XC. All of these proteins exert their biological effects by interacting with G protein -linked transmembrane receptors called chemokine receptors, that are selectively found on the surfaces of their target cells. [Source: Wikipedia]

Genes contained within the family: 45

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CCL1 C-C motif chemokine ligand 1 SCYA1 I-309, TCA3, P500, SISe 17q12
CCL2 C-C motif chemokine ligand 2 SCYA2 MCP1, MCP-1, MCAF, SMC-CF, GDCF-2, HC11, MGC9434 17q12
CCL3 C-C motif chemokine ligand 3 SCYA3 G0S19-1, LD78ALPHA, MIP-1-alpha 17q12
CCL3L1 C-C motif chemokine ligand 3 like 1 D17S1718, SCYA3L, SCYA3L1 G0S19-2, LD78BETA 17q12 alternate reference locus
CCL3L3 C-C motif chemokine ligand 3 like 3 MGC12815 17q12
CCL4 C-C motif chemokine ligand 4 LAG1, SCYA4 MIP-1-beta, Act-2, AT744.1 17q12
CCL4L1 C-C motif chemokine ligand 4 like 1 SCYA4L, CCL4L AT744.2, LAG-1 17q12 alternate reference locus
CCL4L2 C-C motif chemokine ligand 4 like 2 17q12
CCL5 C-C motif chemokine ligand 5 D17S136E, SCYA5 RANTES, SISd, TCP228, MGC17164 17q12
CCL7 C-C motif chemokine ligand 7 SCYA6, SCYA7 MCP-3, NC28, FIC, MARC, MCP3 17q12
CCL8 C-C motif chemokine ligand 8 SCYA8 MCP-2, HC14 17q12
CCL11 C-C motif chemokine ligand 11 SCYA11 eotaxin, MGC22554 17q12
CCL13 C-C motif chemokine ligand 13 SCYA13 MCP-4, NCC-1, SCYL1, CKb10, MGC17134 17q12
CCL14 C-C motif chemokine ligand 14 SCYA14 HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF 17q12
CCL15 C-C motif chemokine ligand 15 SCYA15 HCC-2, NCC-3, SCYL3, MIP-5, Lkn-1, MIP-1d, HMRP-2B 17q12
CCL16 C-C motif chemokine ligand 16 SCYA16 NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1 17q12
CCL17 C-C motif chemokine ligand 17 SCYA17 TARC, ABCD-2 16q21
CCL18 C-C motif chemokine ligand 18 SCYA18 DC-CK1, PARC, AMAC-1, DCCK1, MIP-4, CKb7 17q12
CCL19 C-C motif chemokine ligand 19 SCYA19 ELC, MIP-3b, exodus-3, CKb11 9p13.3
CCL20 C-C motif chemokine ligand 20 SCYA20 LARC, MIP-3a, exodus-1, ST38, CKb4 2q36.3
CCL21 C-C motif chemokine ligand 21 SCYA21 SLC, exodus-2, TCA4, CKb9, 6Ckine, ECL 9p13.3
CCL22 C-C motif chemokine ligand 22 SCYA22 MDC, STCP-1, ABCD-1, DC/B-CK, A-152E5.1, MGC34554 16q21
CCL23 C-C motif chemokine ligand 23 SCYA23 Ckb-8, MPIF-1, MIP-3, CKb8 17q12
CCL24 C-C motif chemokine ligand 24 SCYA24 Ckb-6, MPIF-2, eotaxin-2, MPIF2 7q11.23
CCL25 C-C motif chemokine ligand 25 SCYA25 TECK, Ckb15 19p13.2
CCL26 C-C motif chemokine ligand 26 SCYA26 MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1 7q11.23
CCL27 C-C motif chemokine ligand 27 SCYA27 ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK 9p13.3
CCL28 C-C motif chemokine ligand 28 SCYA28, MEC, CCK1 5p12
CXCL1 C-X-C motif chemokine ligand 1 MGSA, GRO1, FSP SCYB1, GROa, MGSA-a, NAP-3 4q13.3
CXCL2 C-X-C motif chemokine ligand 2 GRO2 SCYB2, GROb, MIP-2a, MGSA-b, CINC-2a 4q13.3
CXCL3 C-X-C motif chemokine ligand 3 GRO3 SCYB3, GROg, MIP-2b, CINC-2b 4q13.3
CXCL5 C-X-C motif chemokine ligand 5 SCYB5 ENA-78 4q13.3
CXCL6 C-X-C motif chemokine ligand 6 SCYB6 GCP-2, CKA-3 4q13.3
CXCL8 C-X-C motif chemokine ligand 8 IL8 SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1 4q13.3
CXCL9 C-X-C motif chemokine ligand 9 CMK, MIG SCYB9, Humig, crg-10 4q21.1
CXCL10 C-X-C motif chemokine ligand 10 INP10, SCYB10 IFI10, IP-10, crg-2, mob-1, C7, gIP-10 4q21.1
CXCL11 C-X-C motif chemokine ligand 11 SCYB9B, SCYB11 H174, b-R1, I-TAC, IP-9 4q21.1
CXCL12 C-X-C motif chemokine ligand 12 SDF1A, SDF1B, SDF1 SCYB12, SDF-1a, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1 10q11.21
CXCL13 C-X-C motif chemokine ligand 13 SCYB13 BLC, BCA-1, BLR1L, ANGIE, ANGIE2 4q21.1
CXCL14 C-X-C motif chemokine ligand 14 SCYB14 BRAK, NJAC, bolekine, Kec, MIP-2g, BMAC, KS1 5q31.1
CXCL16 C-X-C motif chemokine ligand 16 SR-PSOX, CXCLG16, SRPSOX 17p13.2
CXCL17 C-X-C motif chemokine ligand 17 Dcip1, UNQ473, DMC, VCC1 19q13.2
CX3CL1 C-X3-C motif chemokine ligand 1 SCYD1 NTN, C3Xkine, ABCD-3, CXC3C, CXC3, fractalkine, neurotactin 16q21
XCL1 X-C motif chemokine ligand 1 LTN, SCYC1 LPTN, ATAC, SCM-1a, SCM-1 1q24.2
XCL2 X-C motif chemokine ligand 2 SCYC2 SCM-1b 1q24.2

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