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Gene Family: Cathepsins (CTS)

Cathepsin: Cathepsins ( Ancient Greek kata- "down" and hepsein "boil"; abbreviated CTS ) are proteases ( enzymes that degrades proteins) found in all animals as well as other organisms. There are approximately a dozen members of this family, which are distinguished by their structure, catalytic mechanism, and which proteins they cleave. Most of the members become activated at the low pH found in lysosomes. Thus, the activity of this family lies almost entirely within those organelles. There are, however, exceptions such as cathepsin K, which works extracellularly after secretion by osteoclasts in bone resorption. Cathepsins have a vital role in mammalian cellular turnover, e.g. bone resorption. They degrade polypeptides and are distinguished by their substrate specificities. [Source: Wikipedia]

Genes contained within the family: 15

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CTSA cathepsin A GSL, PPGB 20q13.12
CTSB cathepsin B 8p23.1
CTSC cathepsin C PLS, PALS DPP1 11q14.2
CTSD cathepsin D CPSD CLN10 11p15.5
CTSE cathepsin E 1q32.1
CTSF cathepsin F CATSF, CLN13 11q13.2
CTSG cathepsin G CG 14q12
CTSH cathepsin H CPSB ACC-4, ACC-5, ACC4, ACC5 15q25.1
CTSK cathepsin K CTSO2, CTSO, PYCD PKND 1q21.3
CTSL cathepsin L CTSL1 FLJ31037 9q21.33
CTSO cathepsin O CTSO1 4q32.1
CTSS cathepsin S 1q21.3
CTSV cathepsin V CTSL2 CTSU 9q22.33
CTSW cathepsin W 11q13.1
CTSZ cathepsin Z CTSX 20q13.32