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Gene Family: Caspases (CASP)

Also known as : "cysteine-dependent aspartate-directed proteases", "cysteine-aspartic proteases"

Caspase: Caspases, or cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases are a family of cysteine proteases that play essential roles in apoptosis (programmed cell death), necrosis, and inflammation. Caspases are essential in cells for apoptosis, or programmed cell death, in development and most other stages of adult life, and have been termed "executioner" proteins for their roles in the cell. Some caspases are also required in the immune system for the maturation of lymphocytes. Failure of apoptosis is one of the main contributions to tumour development and autoimmune diseases; this, coupled with the unwanted apoptosis that occurs with ischemia or Alzheimer's disease, has stimulated interest in caspases as potential therapeutic targets since they were discovered in the mid-1990s. [Source: Wikipedia]

Genes contained within the family: 13

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CASP1 caspase 1 IL1BC ICE 11q22.3
CASP2 caspase 2 NEDD2 ICH1, PPP1R57, MGC2181 7q34
CASP3 caspase 3 CPP32, CPP32B, Yama, apopain 4q35.1
CASP4 caspase 4 ICE(rel)II, ICH-2, TX 11q22.3
CASP5 caspase 5 ICE(rel)III 11q22.3
CASP6 caspase 6 MCH2 4q25
CASP7 caspase 7 MCH3, CMH-1, ICE-LAP3 10q25.3
CASP8 caspase 8 MCH5, MACH, FLICE, Casp-8 2q33.1
CASP9 caspase 9 MCH6, ICE-LAP6, APAF-3, PPP1R56 1p36.21
CASP10 caspase 10 MCH4 2q33.1
CASP12 caspase 12 (gene/pseudogene) CASP12P1 11q22.3
CASP14 caspase 14 MICE, MGC119078, MGC119079 19p13.12
CASP16P caspase 16, pseudogene CASP16 16p13.3

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