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Gene Family: Carbonic anhydrases (CA)

Also known as : "carbonate dehydratases"

Carbonic anhydrase: The carbonic anhydrases (or carbonate dehydratases ) form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. The active site of most carbonic anhydrases contains a zinc ion; they are therefore classified as metalloenzymes. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. [Source: Wikipedia]

Genes contained within the family: 18

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CA1 carbonic anhydrase 1 Car1 8q21.2
CA2 carbonic anhydrase 2 Car2, CA-II, CAII 8q21.2
CA3 carbonic anhydrase 3 Car3, CAIII 8q21.2
CA4 carbonic anhydrase 4 RP17 CAIV, Car4 17q23.1
CA5A carbonic anhydrase 5A CA5 CAV, CAVA 16q24.2
CA5B carbonic anhydrase 5B Xp22.2
CA6 carbonic anhydrase 6 1p36.23
CA7 carbonic anhydrase 7 16q22.1
CA8 carbonic anhydrase 8 CALS CARP 8q12.1
CA9 carbonic anhydrase 9 MN, CAIX 9p13.3
CA10 carbonic anhydrase 10 CARPX, CA-RPX, HUCEP-15 17q21.33-q22
CA11 carbonic anhydrase 11 CARP2, CARPX1 19q13.33
CA12 carbonic anhydrase 12 HsT18816 15q22.2
CA13 carbonic anhydrase 13 CAXIII, FLJ37995, MGC59868 8q21.2
CA14 carbonic anhydrase 14 1q21.2
CA15P1 carbonic anhydrase 15 pseudogene 1 22q11.21
CA15P2 carbonic anhydrase 15 pseudogene 2 22q11.21
CA15P3 carbonic anhydrase 15 pseudogene 3 22q11.21

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