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Gene Family: Butyrophilins (BTN)

Butyrophilin: Butyrophilin is a family of proteins. Butyrophilin (Btn) genes constitute a subgroup of at least 10 genes in the Ig superfamily identified in human, mouse, cow, goat and other species. The eponymous Btn gene (BTN1A1 in humans; Btn1a1 in mouse) is highly expressed in the secretory epithelium of the mammary gland during lactation. Other homologues are predominantly expressed in skeletal muscle and the intestine and erythroid cells. In contrast, BTN2A1 and 2 and BTN3A1, 2, and 3 are widely expressed in many tissues, suggesting that the structural domains of Btn proteins may have both universal and tissue-specific functions. [Source: Wikipedia]

Genes contained within the family: 15

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BTNL2 butyrophilin like 2 HSBLMHC1, BTL-II, BTN7 6p21.32
BTNL3 butyrophilin like 3 BTNLR, BTN9.1 5q35.3
BTNL8 butyrophilin like 8 FLJ21458, BTN9.2 5q35.3
BTNL9 butyrophilin like 9 FLJ32535, BTN8 5q35.3
BTNL10 butyrophilin like 10 BUTR1, BTN4 1q42.13
BTN1A1 butyrophilin subfamily 1 member A1 BTN BT, BTN1 6p22.2
BTN2A1 butyrophilin subfamily 2 member A1 BT2.1, BTF1, BTN2.1 6p22.2
BTN2A2 butyrophilin subfamily 2 member A2 BTF2, BT2.2, BTN2.2 6p22.2
BTN2A3P butyrophilin subfamily 2 member A3, pseudogene BTN2A3 BTN2.3 6p22.2
BTN3A1 butyrophilin subfamily 3 member A1 BT3.1, BTF5, CD277, BTN3.1 6p22.2
BTN3A2 butyrophilin subfamily 3 member A2 BTN3.2 6p22.2
BTN3A3 butyrophilin subfamily 3 member A3 BTF3, BTN3.3 6p22.2
ERMAP erythroblast membrane associated protein (Scianna blood group) RD, SC BTN5 1p34.2
MOG myelin oligodendrocyte glycoprotein BTNL11, BTN6 6p22.1
SKINT1L Skint1 like (pseudogene) SKINTP, SKINTL BTN12 1p33