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Gene Family: Blood group antigens

Blood group antigen: Protein belonging to the set of cell surface antigens found chiefly, but not solely, on blood cells. More than fifteen different blood group systems are recognised in humans. In most cases the antigenic determinant resides in the carbohydrate chains of membrane glycoproteins or glycolipids. [Source: UniProt]

Genes contained within the family: 41

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ABCB6 ATP binding cassette subfamily B member 6 (Langereis blood group) EST45597, umat, MTABC3 2q35
ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) EST157481, MXR, BCRP, ABCP, CD338 4q22.1
ABO ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase A3GALNT, A3GALT1 9q34.2
ACHE acetylcholinesterase (Cartwright blood group) YT 7q22.1
AQP1 aquaporin 1 (Colton blood group) CO CHIP28 7p14.3
AQP3 aquaporin 3 (Gill blood group) GIL 9p13.3
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) DO DOK1, CD297 12p12.3
A4GALT alpha 1,4-galactosyltransferase (P blood group) P1 A14GALT, Gb3S, P(k) 22q13.2
BCAM basal cell adhesion molecule (Lutheran blood group) LU CD239 19q13.32
BSG basigin (Ok blood group) OK EMMPRIN, CD147 19p13.3
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) B3GALT3 beta3Gal-T3, galT3, P1, GLOB 3q26.1
CD44 CD44 molecule (Indian blood group) MIC4, MDU2, MDU3 IN, MC56, Pgp1, CD44R, HCELL, CSPG8 11p13
CD55 CD55 molecule (Cromer blood group) DAF CR, TC, CROM 1q32.2
CD59 CD59 molecule (CD59 blood group) MIC11, MIN1, MSK21, MIN2, MIN3 16.3A5, EJ16, EJ30, EL32, G344, p18-20 11p13
CD99 CD99 molecule (Xg blood group) MIC2 Xp22.32 and Yp11.3
CD151 CD151 molecule (Raph blood group) SFA-1, PETA-3, TSPAN24, RAPH 11p15.5
CR1 complement C3b/C4b receptor 1 (Knops blood group) CD35, KN 1q32.2
C4A complement C4A (Rodgers blood group) CPAMD2, C4S, CO4, C4, C4A3, C4A2, C4A4, C4A6, C4B, RG 6p21.33
C4B complement C4B (Chido blood group) CPAMD3, C4F, CO4, C4B1, C4B3, CH 6p21.33
ACKR1 atypical chemokine receptor 1 (Duffy blood group) DARC, FY CCBP1, GPD, Dfy, CD234 1q23.2
ERMAP erythroblast membrane associated protein (Scianna blood group) RD, SC BTN5 1p34.2
FUT1 fucosyltransferase 1 (H blood group) H, HSC 19q13.33
FUT3 fucosyltransferase 3 (Lewis blood group) LE CD174 19p13.3
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) UDP-GalNAc, A3GALNT, MGC44848, FS 9q34.2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) NACGT1, II, GCNT5, CCAT IGNT, NAGCT1, bA421M1.1, bA360O19.2, ULG3 6p24.3-p24.2
GYPA glycophorin A (MNS blood group) MNS GPA, MN, CD235a 4q31.21
GYPB glycophorin B (MNS blood group) MNS GPB, SS, CD235b 4q31.21
GYPC glycophorin C (Gerbich blood group) GPC, GYPD, Ge, CD236, CD236R 2q14.3
GYPE glycophorin E (MNS blood group) GPE, MNS 4q31.21
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) LW CD242 19p13.2
KEL Kell blood group, metallo-endopeptidase ECE3, CD238 7q34
RHAG Rh associated glycoprotein RH50A, CD241, SLC42A1 6p12.3
RHCE Rh blood group CcEe antigens RH CD240CE 1p36.11
RHD Rh blood group D antigen RH Rh30a, Rh4, RhPI, RhII, DIIIc, CD240D 1p36.11
SEMA7A semaphorin 7A (John Milton Hagen blood group) SEMAL H-Sema-L, CD108 15q24.1
SLC4A1 solute carrier family 4 member 1 (Diego blood group) EPB3, AE1, DI, WD RTA1A, CD233, FR, SW, WR 17q21.31
SLC14A1 solute carrier family 14 member 1 (Kidd blood group) JK HsT1341, RACH1, RACH2 18q12.3
SLC29A1 solute carrier family 29 member 1 (Augustine blood group) ENT1 6p21.1
SMIM1 small integral membrane protein 1 (Vel blood group) Vel 1p36.32
XG Xg blood group PBDX Xp22.33
XK X-linked Kx blood group NA, NAC XKR1, Kx, X1k Xp21.1

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