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Gene Family: Fucosyltransferases (FUT)

A subset of : Glycosyltransferases

Fucosyltransferase: A fucosyltransferase is an enzyme that transfers an L- fucose sugar from a GDP-fucose ( guanosine diphosphate -fucose) donor substrate to an acceptor substrate. The acceptor substrate can be another sugar such as the transfer of a fucose to a core GlcNAc ( N-acetylglucosamine ) sugar as in the case of N-linked glycosylation, or to a protein, as in the case of O -linked glycosylation produced by O -fucosyltransferase. There are various fucosyltransferases in mammals, the vast majority of which, are located in the Golgi apparatus. The O -fucosyltransferases have recently been shown to localize to the endoplasmic reticulum (ER). Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates attached to lipids or proteins. Galactoside 3(4)-L-fucosyltransferase ( EC 2.4.1.65 ) belongs to the Lewis blood group system and is associated with Le(a/b) antigen. [Source: Wikipedia]

Genes contained within the family: 13

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
FUT1 fucosyltransferase 1 (H blood group) H, HSC 19q13.33
FUT2 fucosyltransferase 2 SE sej, Se2, SEC2 19q13.33
FUT3 fucosyltransferase 3 (Lewis blood group) LE CD174 19p13.3
FUT4 fucosyltransferase 4 CD15, FCT3A, ELFT FUC-TIV 11q21
FUT5 fucosyltransferase 5 FUC-TV 19p13.3
FUT6 fucosyltransferase 6 FT1A, FCT3A, FucT-VI, FLJ40754 19p13.3
FUT7 fucosyltransferase 7 9q34.3
FUT8 fucosyltransferase 8 14q23.3
FUT9 fucosyltransferase 9 Fuc-TIX 6q16.1
FUT10 fucosyltransferase 10 8p12
FUT11 fucosyltransferase 11 MGC33202 10q22.2
POFUT1 protein O-fucosyltransferase 1 O-FUT, FUT12, O-Fuc-T, KIAA0180 20q11.21
POFUT2 protein O-fucosyltransferase 2 C21orf80 KIAA0958, FUT13 21q22.3