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Gene Family: Basic helix-loop-helix proteins (BHLH)

Basic helix-loop-helix: A basic helix-loop-helix (bHLH) is a protein structural motif that characterizes a family of transcription factors. The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino acid residues that facilitate DNA binding. [Source: Wikipedia]

Genes contained within the family: 110

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
NEUROD2 neuronal differentiation 2 bHLHa1, NDRF 17q12
NEUROD6 neuronal differentiation 6 Nex1, Math-2, bHLHa2, NEX1M, Atoh2 7p14.3
NEUROD1 neuronal differentiation 1 NEUROD MODY6, bHLHa3, NeuroD, BHF-1, BETA2 2q31.3
NEUROD4 neuronal differentiation 4 Atoh3, MATH-3, ATH-3, bHLHa4 12q13.13
NEUROG1 neurogenin 1 NEUROD3 bHLHa6, Math4C, ngn1, AKA 5q31.1
NEUROG3 neurogenin 3 Math4B, Atoh5, ngn3, bHLHa7 10q22.1
NEUROG2 neurogenin 2 Atoh4, bHLHa8, ngn-2, NGN2, Math4A 4q25
BHLHA9 basic helix-loop-helix family member a9 bHLHa9, BHLHF42 17p13.3
ATOH7 atonal bHLH transcription factor 7 Math5, bHLHa13 10q21.3
ATOH1 atonal bHLH transcription factor 1 MATH-1, bHLHa14, Math1, HATH1 4q22.2
BHLHA15 basic helix-loop-helix family member a15 BHLHB8 MIST1, bHLHa15 7q21.3
TAL1 TAL bHLH transcription factor 1, erythroid differentiation factor TCL5 SCL, bHLHa17 1p33
LYL1 LYL1, basic helix-loop-helix family member bHLHa18 19p13.13
TAL2 TAL bHLH transcription factor 2 bHLHa19 9q31.2
ATOH8 atonal bHLH transcription factor 8 bHLHa21, HATH6, FLJ14708 2p11.2
MSC musculin bHLHa22, ABF-1 8q13.3
TCF21 transcription factor 21 bHLHa23, POD1 6q23.2
TCF23 transcription factor 23 bHLHa24, OUT 2p23.3
TCF24 transcription factor 24 bHLHa25 8q13.1
HAND2 heart and neural crest derivatives expressed 2 bHLHa26, Thing2, Hed, dHand 4q34.1
HAND1 heart and neural crest derivatives expressed 1 Hxt, Thing1, eHand, bHLHa27 5q33.2
PTF1A pancreas specific transcription factor, 1a bHLHa29, PTF1-p48 10p12.2
FERD3L Fer3 like bHLH transcription factor N-TWIST, bHLHa31, NATO3 7p21.1
NHLH2 nescient helix-loop-helix 2 HEN2 bHLHa34, NSCL2 1p13.1
NHLH1 nescient helix-loop-helix 1 HEN1 bHLHa35, NSCL, NSCL1 1q23.2
TWIST1 twist family bHLH transcription factor 1 ACS3, BPES3, TWIST, CRS bHLHa38, H-twist, SCS, CRS1, BPES2 7p21.1
TWIST2 twist family bHLH transcription factor 2 bHLHa39, Dermo-1, DERMO1 2q37.3
TCF15 transcription factor 15 bHLHa40, PARAXIS, EC2 20p13
ASCL3 achaete-scute family bHLH transcription factor 3 HASH3, bHLHa42, Sgn1 11p15.4
ASCL4 achaete-scute family bHLH transcription factor 4 bHLHa44, HASH4 12q23.3
ASCL2 achaete-scute family bHLH transcription factor 2 ASH2, bHLHa45, HASH2 11p15.5
ASCL1 achaete-scute family bHLH transcription factor 1 bHLHa46, HASH1, ASH1 12q23.2
ASCL5 achaete-scute family bHLH transcription factor 5 bHLHa47 1q32.1
SCX scleraxis bHLH transcription factor SCXA, SCXB bHLHa41, bHLHa48 8q24.3
BHLHB9 basic helix-loop-helix family member b9 p60TRP, KIAA1701, GASP3 Xq22.1
USF1 upstream transcription factor 1 bHLHb11, UEF, MLTFI 1q23.3
USF2 upstream transcription factor 2, c-fos interacting FIP, bHLHb12 19q13
TCF4 transcription factor 4 SEF2-1B, ITF2, bHLHb19, E2-2 18q21.2
TCF12 transcription factor 12 HsT17266, HTF4, bHLHb20, HEB 15q21.3
TCF3 transcription factor 3 MGC129647, bHLHb21, E2A, VDIR, E47, MGC129648, ITF1 19p13.3
ID1 inhibitor of DNA binding 1, HLH protein bHLHb24, dJ857M17.1.2 20q11.21
ID3 inhibitor of DNA binding 3, HLH protein bHLHb25, HEIR-1 1p36.12
ID2 inhibitor of DNA binding 2 GIG8, bHLHb26 2p25.1
ID4 inhibitor of DNA binding 4, HLH protein bHLHb27 6p22.3
HEY1 hes related family bHLH transcription factor with YRPW motif 1 bHLHb31, CHF-2, HRT-1, HESR1, CHF2, HERP2, HESR-1 8q21.13
HEY2 hes related family bHLH transcription factor with YRPW motif 2 bHLHb32, HESR2, HERP1 6q22.31
HEYL hes related family bHLH transcription factor with YRPW motif-like HEY3, HESR3, bHLHb33 1p34.2
HES7 hes family bHLH transcription factor 7 bHLHb37 17p13.1
HES5 hes family bHLH transcription factor 5 bHLHb38 1p36.32
HES1 hes family bHLH transcription factor 1 HRY HES-1, Hes1, bHLHb39, FLJ20408 3q29
HES2 hes family bHLH transcription factor 2 bHLHb40 1p36.31
HES6 hes family bHLH transcription factor 6 bHLHb41 2q37.3
HES4 hes family bHLH transcription factor 4 bHLHb42 1p36.33
HES3 hes family bHLH transcription factor 3 bHLHb43 1p36.31
HELT helt bHLH transcription factor bHLHb44, HESL, HCM1228, MEGANE, Mgn 4q35.1
MYOD1 myogenic differentiation 1 MYF3 PUM, bHLHc1, MYOD 11p15.1
MYF5 myogenic factor 5 bHLHc2 12q21.31
MYOG myogenin MYF4 bHLHc3 1q32.1
MYF6 myogenic factor 6 MRF4, bHLHc4 12q21.31
MESP1 mesoderm posterior bHLH transcription factor 1 bHLHc5, MGC10676 15q26.1
MESP2 mesoderm posterior bHLH transcription factor 2 SCDO2, bHLHc6 15q26.1
FIGLA folliculogenesis specific bHLH transcription factor bHLHc8 2p13.3
MXI1 MAX interactor 1, dimerization protein MAD2, MXI, MXD2, bHLHc11 10q25.2
MXD4 MAX dimerization protein 4 bHLHc12, MST149, MSTP149, MAD4 4p16.3
MXD3 MAX dimerization protein 3 bHLHc13, MAD3 5q35.3
TFAP4 transcription factor AP-4 bHLHc41, AP-4 16p13.3
MXD1 MAX dimerization protein 1 MAD bHLHc58, MAD1 2p13.3
SREBF1 sterol regulatory element binding transcription factor 1 SREBP1a, SREBP1, SREBP-1c, bHLHd1 17p11.2
SREBF2 sterol regulatory element binding transcription factor 2 bHLHd2, SREBP2 22q13.2
MNT MAX network transcriptional repressor ROX, MXD6, MAD6, bHLHd3 17p13.3
MAX MYC associated factor X bHLHd7, bHLHd5, bHLHd8, bHLHd6, bHLHd4 14q23.3
MLX MLX, MAX dimerization protein TCFL4 bHLHd13, MXD7, MAD7 17q21.1
MLXIPL MLX interacting protein like WBSCR14 bHLHd14, MONDOB, MIO, WS-bHLH, CHREBP 7q11.23
ARNT2 aryl hydrocarbon receptor nuclear translocator 2 KIAA0307, bHLHe1 15q25.1
ARNT aryl hydrocarbon receptor nuclear translocator bHLHe2, HIF-1beta 1q21.3
ARNTL aryl hydrocarbon receptor nuclear translocator like PASD3, BMAL1, MOP3, JAP3, bHLHe5 11p15.3
ARNTL2 aryl hydrocarbon receptor nuclear translocator like 2 MOP9, bHLHe6, PASD9, CLIF, BMAL2 12p11.23
CLOCK clock circadian regulator KIAA0334, bHLHe8, KAT13D 4q12
NPAS2 neuronal PAS domain protein 2 PASD4, MOP4, bHLHe9 2q11.2
NPAS1 neuronal PAS domain protein 1 bHLHe11, MOP5, PASD5 19q13.32
NPAS3 neuronal PAS domain protein 3 MOP6, bHLHe12, PASD6 14q13.1
SIM1 single-minded family bHLH transcription factor 1 bHLHe14 6q16.3
SIM2 single-minded family bHLH transcription factor 2 SIM MGC119447, bHLHe15 21q22.13
HIF3A hypoxia inducible factor 3 alpha subunit MOP7, IPAS, bHLHe17, PASD7 19q13.32
OLIG2 oligodendrocyte transcription factor 2 PRKCBP2, BHLHB1 OLIGO2, RACK17, bHLHe19 21q22.11
OLIG3 oligodendrocyte transcription factor 3 bHLHe20, Bhlhb7 6q23.3
OLIG1 oligodendrocyte transcription factor 1 BHLHB6, bHLHe21 21q22.11
BHLHE22 basic helix-loop-helix family member e22 TNRC20, BHLHB5 CAGL85, Beta3, bHLHe22 8q12.3
BHLHE23 basic helix-loop-helix family member e23 BHLHB4 bA305P22.3, Beta4, bHLHe23 20q13.33
MITF melanogenesis associated transcription factor WS2A, WS2 bHLHe32, MI 3p13
TFE3 transcription factor binding to IGHM enhancer 3 TFEA, bHLHe33 Xp11.23
TFEC transcription factor EC bHLHe34, TCFEC, TFECL 7q31.2
TFEB transcription factor EB bHLHe35, TCFEB 6p21.1
MLXIP MLX interacting protein MIR, KIAA0867, bHLHe36, MONDOA 12q21.31
MYCN MYCN proto-oncogene, bHLH transcription factor NMYC bHLHe37, N-myc, MYCNOT 2p24.3
MYCL MYCL proto-oncogene, bHLH transcription factor MYCL1 bHLHe38, LMYC 1p34.2
MYC MYC proto-oncogene, bHLH transcription factor MYCC, bHLHe39, c-Myc 8q24.21
BHLHE40 basic helix-loop-helix family member e40 STRA13, BHLHB2 DEC1, bHLHe40, SHARP2, Clast5 3p26.1
BHLHE41 basic helix-loop-helix family member e41 BHLHB3 DEC2, SHARP-1, SHARP1, bHLHe41 12p12.1
NCOA3 nuclear receptor coactivator 3 SRC-3, KAT13B, CAGH16, ACTR, p/CIP, bHLHe42, TRAM-1, AIB1, TNRC16, SRC3, RAC3 20q13.12
EPAS1 endothelial PAS domain protein 1 HLF, HIF2A, bHLHe73, MOP2, PASD2 2p21
NCOA1 nuclear receptor coactivator 1 RIP160, bHLHe74, NCoA-1, F-SRC-1, SRC1, KAT13A 2p23.3
NCOA2 nuclear receptor coactivator 2 TIF2, bHLHe75, NCoA-2, GRIP1, KAT13C 8q13.3
AHR aryl hydrocarbon receptor bHLHe76 7p21.1
AHRR aryl-hydrocarbon receptor repressor AHH, AHHR KIAA1234, bHLHe77 5p15.33
HIF1A hypoxia inducible factor 1 alpha subunit bHLHe78, HIF1, HIF-1alpha, MOP1, PASD8 14q23.2
NPAS4 neuronal PAS domain protein 4 bHLHe79, Le-PAS, NXF, PASD10 11q13.2
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 C9orf157 NOHLH, bA100C15.3, SPATA27, bHLHe80, TEB2 9q34.3
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 TEB1, SPATA28, bHLHe81, FLJ20449 13q13.3
TCFL5 transcription factor like 5 CHA, E2BP-1, bHLHe82, Figlb 20q13.33

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