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Gene Family: Baculoviral IAP repeat containing (BIRC)

Also known as : "inhibitor of apoptosis domain containing", "IAP repeat containing", "Baculovirus inhibitor of apoptosis protein repeat containing"

Baculoviral IAP repeat: The inhibitor of apoptosis domain - also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR - is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6. BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion. They are typically composed of 4-5 alpha helices and a three-stranded beta sheet. [Source: Wikipedia]

Genes contained within the family: 8

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
NAIP NLR family apoptosis inhibitory protein BIRC1 NLRB1 5q13.2
BIRC2 baculoviral IAP repeat containing 2 API1 cIAP1, hiap-2, MIHB, RNF48, c-IAP1 11q22.2
BIRC3 baculoviral IAP repeat containing 3 API2 cIAP2, hiap-1, MIHC, RNF49, MALT2, c-IAP2 11q22.2
XIAP X-linked inhibitor of apoptosis BIRC4, API3 hILP Xq25
BIRC5 baculoviral IAP repeat containing 5 API4 EPR-1, survivin 17q25.3
BIRC6 baculoviral IAP repeat containing 6 BRUCE 2p22.3
BIRC7 baculoviral IAP repeat containing 7 mliap, ML-IAP, KIAP, RNF50 20q13.33
BIRC8 baculoviral IAP repeat containing 8 ILP-2, hILP2 19q13.42