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Gene Family: Arachidonate lipoxygenases (ALOX)

Arachidonate lipoxygenases: Lipoxygenases ( EC 1.13.11.- ) are a family of iron -containing enzymes that catalyse the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene structure. It catalyses the following reaction: fatty acid + O 2 = fatty acid hydroperoxide Lipoxygenases are found in plants, animals and fungi. Products of lipoxygenases are involved in diverse cell functions. [Source: Wikipedia]

Genes contained within the family: 6

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ALOXE3 arachidonate lipoxygenase 3 eLOX3, E-LOX 17p13.1
ALOX5 arachidonate 5-lipoxygenase 5-LOX 10q11.21
ALOX12 arachidonate 12-lipoxygenase, 12S type 12S-LOX 17p13.1
ALOX12B arachidonate 12-lipoxygenase, 12R type 12R-LOX 17p13.1
ALOX15 arachidonate 15-lipoxygenase 15-LOX-1 17p13.2
ALOX15B arachidonate 15-lipoxygenase, type B 15-LOX-2 17p13.1

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