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Gene Family: Apolipoprotein B mRNA editing enzyme catalytic subunits (APOBEC)

APOBEC: APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like") is a family of evolutionary conserved proteins. A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalytic domain. More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine deamination. RNA editing by APOBEC-1 requires homodimerisation and this complex interacts with RNA binding proteins to form the editosome. [Source: Wikipedia]

Genes contained within the family: 12

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AICDA activation induced cytidine deaminase HIGM2, CDA2, ARP2, AID 12p13.31
APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 BEDP, CDAR1, APOBEC-1, HEPR 12p13.31
APOBEC2 apolipoprotein B mRNA editing enzyme catalytic subunit 2 ARCD1, ARP1 6p21.1
APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A ARP3, PHRBN 22q13.1
APOBEC3A_B APOBEC3A and APOBEC3B deletion hybrid 22q13 alternate reference locus
APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B PHRBNL, FLJ21201 22q13.1
APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C APOBEC1L, PBI, bK150C2.3, ARDC2, ARDC4, ARP5 22q13.1
APOBEC3D apolipoprotein B mRNA editing enzyme catalytic subunit 3D APOBEC3E ARP6, APOBEC3DE 22q13.1
APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F ARP8, BK150C2.4.MRNA, KA6 22q13.1
APOBEC3G apolipoprotein B mRNA editing enzyme catalytic subunit 3G CEM15, MDS019, dJ494G10.1, FLJ12740, bK150C2.7 22q13.1
APOBEC3H apolipoprotein B mRNA editing enzyme catalytic subunit 3H ARP10 22q13.1
APOBEC4 apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 C1orf169 MGC26594, FLJ25691, RP1-127C7.4 1q25.3