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Gene Family: Annexins (ANXA)

Annexin: Annexin is a common name for a group of cellular proteins. They are mostly found in eukaryotic organisms (animal, plant and fungi). In humans, the annexins are found inside the cell. However some annexins (Annexin A1, Annexin A2, and Annexin A5) have also been found outside the cellular environment, for example, in blood. How the annexins are transported out of the cell into the blood is a mystery because they lack a signal peptide necessary for proteins to be transported out of the cell. Annexin is also known as lipocortin. Lipocortins suppress phospholipase A2. Increased expression of the gene coding for annexin-1 is one of the mechanisms by which glucocorticoids (such as cortisol ) inhibit inflammation. [Source: Wikipedia]

Genes contained within the family: 13

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ANXA1 annexin A1 ANX1, LPC1 9q21.13
ANXA2 annexin A2 ANX2, ANX2L4, CAL1H, LPC2D LIP2 15q22.2
ANXA3 annexin A3 ANX3 4q21.21
ANXA4 annexin A4 ANX4 2p13.3
ANXA5 annexin A5 ENX2, ANX5 4q27
ANXA6 annexin A6 ANX6 5q33.1
ANXA7 annexin A7 ANX7 10q22.2
ANXA8 annexin A8 ANX8 10q11.22
ANXA8L1 annexin A8 like 1 ANXA8L2 bA301J7.3, bA145E20.2 10q11.22
ANXA9 annexin A9 ANX31 1q21.3
ANXA10 annexin A10 ANX14 4q32.3
ANXA11 annexin A11 ANX11 10q22.3
ANXA13 annexin A13 ANX13 8q24.13

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