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Gene Family: Anaphase promoting complex (ANAPC)

Anaphase-promoting complex: This article refers to the cell-cycle regulatory complex, APC/C. For the tumor suppressor APC, in which mutations lead to colon cancer, see Adenomatous polyposis coli. Anaphase-Promoting Complex (also called the cyclosome or APCC is a large complex of 11-13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other parts of the APC/C still have unknown functions, but are highly conserved. It was the discovery of the APC/C (and SCF ) and their key role in eukaryotic cell reproduction that established once and for all the importance of ubiquitin -mediated proteolysis in eukaryotic cell biology. Once perceived as a system exclusively involved in removing damaged protein from the cell, ubiquitination and subsequent protein degradation by the proteasome is now perceived as a universal regulatory mechanism for signal transduction whose importance approaches that of protein phosphorylation. In 2014, the APC/C was mapped in 3D at a resolution of less than a nanometre, which also uncovered its secondary structure. Researchers have claimed this finding could transform the understanding of cancer and reveal new binding sites for future cancer drugs. [Source: Wikipedia]

Genes contained within the family: 14

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ANAPC1 anaphase promoting complex subunit 1 MCPR, TSG24, APC1 2q13
ANAPC2 anaphase promoting complex subunit 2 APC2, KIAA1406 9q34.3
CDC27 cell division cycle 27 D0S1430E, D17S978E NUC2, ANAPC3, APC3 17q21.32
ANAPC4 anaphase promoting complex subunit 4 APC4 4p15.2
ANAPC5 anaphase promoting complex subunit 5 APC5 12q24.31
CDC16 cell division cycle 16 ANAPC6, CUT9, APC6 13q34
ANAPC7 anaphase promoting complex subunit 7 APC7 12q24.11
CDC23 cell division cycle 23 CUT23, ANAPC8, APC8 5q31.2
ANAPC10 anaphase promoting complex subunit 10 APC10, DOC1, DKFZP564L0562 4q31.21
ANAPC11 anaphase promoting complex subunit 11 HSPC214, APC11, Apc11p, MGC882 17q25.3
CDC26 cell division cycle 26 C9orf17 APC12, ANAPC12 9q32
ANAPC13 anaphase promoting complex subunit 13 SWM1, APC13, DKFZP566D193 3q22.2
ANAPC15 anaphase promoting complex subunit 15 C11orf51 HSPC020, DKFZP564M082, APC15 11q13.4
ANAPC16 anaphase promoting complex subunit 16 C10orf104 bA570G20.3, FLJ33728, APC16, CENP-27 10q22.1

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