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Gene Family: Miro like atypical Rho GTPases

Miro-like proteins: Mitochondrial Rho proteins (Miro-1, Q8IXI2 [encoded by RHOT1] and Miro-2, Q8IXI1 [encoded by RHOT2]), are atypical Rho GTPases. They have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (PF00036), that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis. [Source: Pfam]

Genes contained within the family: 2

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
RHOT1 ras homolog family member T1 ARHT1 MIRO-1, FLJ11040 17q11.2
RHOT2 ras homolog family member T2 C16orf39, ARHT2 MIRO-2 16p13.3