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Gene Family: ARF GTPase family

Also known as : "ADP ribosylation factor GTPase family"

ARF family: ADP Ribosylation Factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling. The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular traffic. They are the founding members of a growing family that includes Arl (Arf-like), Arp [ARFRP] (Arf-related proteins) and the remotely related Sar (Secretion-associated and Ras-related) proteins. [Source: Wikipedia]

Genes contained within the family: 31

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TRIM23 tripartite motif containing 23 ARFD1 ARD1, RNF46 5q12.3
ARF1 ADP ribosylation factor 1 1q42.13
ARF3 ADP ribosylation factor 3 12q13.12
ARF4 ADP ribosylation factor 4 ARF2 3p14.3
ARF5 ADP ribosylation factor 5 7q32.1
ARF6 ADP ribosylation factor 6 14q21.3
ARL1 ADP ribosylation factor like GTPase 1 ARFL1 12q23.2
ARL2 ADP ribosylation factor like GTPase 2 ARFL2 11q13.1
ARL3 ADP ribosylation factor like GTPase 3 ARFL3 10q24.32
ARL4A ADP ribosylation factor like GTPase 4A ARL4 7p21.3
ARL4C ADP ribosylation factor like GTPase 4C ARL7 LAK 2q37.1
ARL4D ADP ribosylation factor like GTPase 4D ARF4L 17q21.31
ARL5A ADP ribosylation factor like GTPase 5A ARL5 2q23.3
ARL5B ADP ribosylation factor like GTPase 5B ARL8 10p12.31
ARL5C ADP ribosylation factor like GTPase 5C ARL12 17q12
ARL6 ADP ribosylation factor like GTPase 6 BBS3 RP55 3q11.2
ARL8A ADP ribosylation factor like GTPase 8A ARL10B FLJ45195, Gie2 1q32.1
ARL8B ADP ribosylation factor like GTPase 8B ARL10C FLJ10702, Gie1 3p26.1
ARL9 ADP ribosylation factor like GTPase 9 4q12
ARL10 ADP ribosylation factor like GTPase 10 ARL10A 5q35.2
ARL11 ADP ribosylation factor like GTPase 11 ARLTS1, FLJ33930 13q14.2
ARL13A ADP ribosylation factor like GTPase 13A ARL13 Xq22.1
ARL13B ADP ribosylation factor like GTPase 13B ARL2L1 DKFZp761H079, JBTS8 3q11.1-q11.2
ARL14 ADP ribosylation factor like GTPase 14 ARF7 FLJ22595 3q25.33
ARL15 ADP ribosylation factor like GTPase 15 ARFRP2 FLJ20051 5q11.2
ARL16 ADP ribosylation factor like GTPase 16 17q25.3
ARL17A ADP ribosylation factor like GTPase 17A ARF1P2, ARL17P1 17q21.31
ARL17B ADP ribosylation factor like GTPase 17B ARL17 17q21.31
ARFRP1 ADP ribosylation factor related protein 1 ARL18, Arp1, ARP 20q13.33
SAR1A secretion associated Ras related GTPase 1A SARA1 SAR1, Sara 10q22.1
SAR1B secretion associated Ras related GTPase 1B SARA2 5q31.1

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