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Gene Family: Immunoglobulin kappa locus at 2p11.2 (IGK)

A subset of : Immunoglobulin kappa

IGK locus: The human IGK locus is at 2p11.2 and contains IGKV (variable) genes, IGKJ (joining) genes and one IGKC (constant) gene. Most individuals have two clusters of the IGKV genes resulting from a duplication. The clusters are designated as either proximal or distal to the IGKC gene. Genes from the distal cluster are denoted with a “D” in the symbol while those without a “D” are located in the proximal cluster. [Source: HGNC]

Genes contained within the family: 83

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
IGK immunoglobulin kappa locus IGK@ 2p11.2
IGKV1-5 immunoglobulin kappa variable 1-5 2p11.2
IGKV1-6 immunoglobulin kappa variable 1-6 2p11.2
IGKV1-8 immunoglobulin kappa variable 1-8 IGKV18, L9 2p11.2
IGKV1-9 immunoglobulin kappa variable 1-9 IGKV19, L8 2p11.2
IGKV1-12 immunoglobulin kappa variable 1-12 IGKV112, L19 2p11.2
IGKV1-13 immunoglobulin kappa variable 1-13 (gene/pseudogene) 2p11.2
IGKV1-16 immunoglobulin kappa variable 1-16 IGKV116, L1 2p11.2
IGKV1-17 immunoglobulin kappa variable 1-17 IGKV117, A30 2p11.2
IGKV1-22 immunoglobulin kappa variable 1-22 (pseudogene) 2p11.2
IGKV1-27 immunoglobulin kappa variable 1-27 IGKV127, A20 2p11.2
IGKV1-32 immunoglobulin kappa variable 1-32 (pseudogene) 2p11.2
IGKV1-33 immunoglobulin kappa variable 1-33 IGKV133, O18 2p11.2
IGKV1-35 immunoglobulin kappa variable 1-35 (pseudogene) 2p11.2
IGKV1-37 immunoglobulin kappa variable 1-37 (non-functional) IGKV137, O14 2p11.2
IGKV1-39 immunoglobulin kappa variable 1-39 (gene/pseudogene) 2p11.2
IGKV1D-8 immunoglobulin kappa variable 1D-8 2p11.2
IGKV1D-12 immunoglobulin kappa variable 1D-12 2p11.2
IGKV1D-13 immunoglobulin kappa variable 1D-13 2p11.2
IGKV1D-16 immunoglobulin kappa variable 1D-16 2p11.2
IGKV1D-17 immunoglobulin kappa variable 1D-17 2p11.2
IGKV1D-22 immunoglobulin kappa variable 1D-22 (pseudogene) 2p11.2
IGKV1D-27 immunoglobulin kappa variable 1D-27 (pseudogene) 2p11.2
IGKV1D-32 immunoglobulin kappa variable 1D-32 (pseudogene) 2p11.2
IGKV1D-33 immunoglobulin kappa variable 1D-33 2p11.2
IGKV1D-35 immunoglobulin kappa variable 1D-35 (pseudogene) 2p11.2
IGKV1D-37 immunoglobulin kappa variable 1D-37 (non-functional) IGKV1D37, O4 2p11.2
IGKV1D-39 immunoglobulin kappa variable 1D-39 2p11.2
IGKV1D-42 immunoglobulin kappa variable 1D-42 (non-functional) 2p11.2
IGKV1D-43 immunoglobulin kappa variable 1D-43 2p11.2
IGKV2-4 immunoglobulin kappa variable 2-4 (pseudogene) 2p11.2
IGKV2-10 immunoglobulin kappa variable 2-10 (pseudogene) 2p11.2
IGKV2-14 immunoglobulin kappa variable 2-14 (pseudogene) 2p11.2
IGKV2-18 immunoglobulin kappa variable 2-18 (pseudogene) 2p11.2
IGKV2-19 immunoglobulin kappa variable 2-19 (pseudogene) 2p11.2
IGKV2-23 immunoglobulin kappa variable 2-23 (pseudogene) 2p11.2
IGKV2-24 immunoglobulin kappa variable 2-24 2p11.2
IGKV2-26 immunoglobulin kappa variable 2-26 (pseudogene) 2p11.2
IGKV2-28 immunoglobulin kappa variable 2-28 2p11.2
IGKV2-29 immunoglobulin kappa variable 2-29 (gene/pseudogene) 2p11.2
IGKV2-30 immunoglobulin kappa variable 2-30 2p11.2
IGKV2-36 immunoglobulin kappa variable 2-36 (pseudogene) 2p11.2
IGKV2-38 immunoglobulin kappa variable 2-38 (pseudogene) 2p11.2
IGKV2-40 immunoglobulin kappa variable 2-40 2p11.2
IGKV2D-10 immunoglobulin kappa variable 2D-10 (pseudogene) 2p11.2
IGKV2D-14 immunoglobulin kappa variable 2D-14 (pseudogene) 2p11.2
IGKV2D-18 immunoglobulin kappa variable 2D-18 (pseudogene) 2p11.2
IGKV2D-19 immunoglobulin kappa variable 2D-19 (pseudogene) 2p11.2
IGKV2D-23 immunoglobulin kappa variable 2D-23 (pseudogene) 2p11.2
IGKV2D-24 immunoglobulin kappa variable 2D-24 (non-functional) 2p11.2
IGKV2D-26 immunoglobulin kappa variable 2D-26 2p11.2
IGKV2D-28 immunoglobulin kappa variable 2D-28 2p11.2
IGKV2D-29 immunoglobulin kappa variable 2D-29 2p11.2
IGKV2D-30 immunoglobulin kappa variable 2D-30 2p11.2
IGKV2D-36 immunoglobulin kappa variable 2D-36 (pseudogene) 2p11.2
IGKV2D-38 immunoglobulin kappa variable 2D-38 (pseudogene) 2p11.2
IGKV2D-40 immunoglobulin kappa variable 2D-40 2p11.2
IGKV3-7 immunoglobulin kappa variable 3-7 (non-functional) 2p11.2
IGKV3-11 immunoglobulin kappa variable 3-11 2p11.2
IGKV3D-7 immunoglobulin kappa variable 3D-7 2p11.2
IGKV3-15 immunoglobulin kappa variable 3-15 2p11.2
IGKV3D-11 immunoglobulin kappa variable 3D-11 2p11.2
IGKV4-1 immunoglobulin kappa variable 4-1 IGKV41, B3 2p11.2
IGKV3-20 immunoglobulin kappa variable 3-20 2p11.2
IGKV3D-15 immunoglobulin kappa variable 3D-15 (gene/pseudogene) 2p11.2
IGKV5-2 immunoglobulin kappa variable 5-2 IGKV52, B2 2p11.2
IGKV3-25 immunoglobulin kappa variable 3-25 (pseudogene) 2p11.2
IGKV3D-20 immunoglobulin kappa variable 3D-20 2p11.2
IGKV6-21 immunoglobulin kappa variable 6-21 (non-functional) IGKV621, A26 2p11.2
IGKV3-31 immunoglobulin kappa variable 3-31 (pseudogene) 2p11.2
IGKV3D-25 immunoglobulin kappa variable 3D-25 (pseudogene) 2p11.2
IGKV6D-21 immunoglobulin kappa variable 6D-21 (non-functional) IGKV6D21, A10 2p11.2
IGKV3-34 immunoglobulin kappa variable 3-34 (pseudogene) 2p11.2
IGKV3D-31 immunoglobulin kappa variable 3D-31 (pseudogene) 2p11.2
IGKV6D-41 immunoglobulin kappa variable 6D-41 (non-functional) 2p11.2
IGKV3D-34 immunoglobulin kappa variable 3D-34 (pseudogene) 2p11.2
IGKV7-3 immunoglobulin kappa variable 7-3 (pseudogene) 2p11.2
IGKJ1 immunoglobulin kappa joining 1 J1 2p11.2
IGKJ2 immunoglobulin kappa joining 2 J2 2p11.2
IGKJ3 immunoglobulin kappa joining 3 2p11.2
IGKJ4 immunoglobulin kappa joining 4 2p11.2
IGKJ5 immunoglobulin kappa joining 5 2p11.2
IGKC immunoglobulin kappa constant HCAK1 2p11.2

Comments

For further reading, please see: Lefranc M.-P. and Lefranc G. The Immunoglobulin FactsBook, Academic Press, 2001

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11549845,24600447