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Gene Family: Gap junction proteins (GJ)

Also known as : "Connexins"

Gap junction proteins: Connexins, or gap junction proteins, are a family of structurally related transmembrane proteins that assemble to form vertebrate gap junctions (an entirely different family of proteins, the innexins, form gap junctions in invertebrates). Each gap junction is composed of two hemichannels, or connexons, which are themselves each constructed out of six connexin molecules. Gap junctions are essential for many physiological processes, such as the coordinated depolarization of cardiac muscle, proper embryonic development, and the conducted response in microvasculature. For this reason, mutations in connexin-encoding genes can lead to functional and developmental abnormalities. [Source: Wikipedia]

Genes contained within the family: 22

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GJA1 gap junction protein alpha 1 ODDD, GJAL CX43, ODD, ODOD, SDTY3 6q22.31
GJA3 gap junction protein alpha 3 CZP3 CX46 13q12.11
GJA4 gap junction protein alpha 4 CX37 1p34.3
GJA5 gap junction protein alpha 5 CX40 1q21.2
GJA6P gap junction protein alpha 6 pseudogene Xp22.13
GJA8 gap junction protein alpha 8 CAE1, CZP1, CAE CX50 1q21.2
GJA9 gap junction protein alpha 9 GJA10 CX59, CX58 1p34.3
GJA10 gap junction protein alpha 10 CX62 6q15
GJB1 gap junction protein beta 1 CMTX1, CMTX CX32 Xq13.1
GJB2 gap junction protein beta 2 DFNB1, DFNA3 CX26, NSRD1 13q12.11
GJB3 gap junction protein beta 3 DFNA2, EKV CX31 1p34.3
GJB4 gap junction protein beta 4 CX30.3 1p34.3
GJB5 gap junction protein beta 5 CX31.1 1p34.3
GJB6 gap junction protein beta 6 DFNA3, ED2 EDH, HED, CX30 13q12.11
GJB7 gap junction protein beta 7 CX25, bA136M9.1 6q14.3-q15
GJC1 gap junction protein gamma 1 GJA7 CX45 17q21.31
GJC2 gap junction protein gamma 2 GJA12 CX47, CX46.6, SPG44 1q42.13
GJC3 gap junction protein gamma 3 GJE1 CX30.2 7q22.1
GJD2 gap junction protein delta 2 GJA9 CX36 15q14
GJD3 gap junction protein delta 3 GJC1 CX31.9, GJA11, Cx30.2 17q21.2
GJD4 gap junction protein delta 4 CX40.1, FLJ90023 10p11.21
GJE1 gap junction protein epsilon 1 CX23 6q24.1

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