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Gene Family: Acid sensing ion channel subunits (ASIC)

Also known as : "Acid-Sensing Ion Channels", "Acid-sensing (proton-gated) ion channels", "Acid sensing (proton gated) ion channels", "Acid sensing ion channels"

Acid-Sensing Ion Channels: Acid-Sensing Ion Channels (ASICs) are neuronal voltage-insensitive cationic channels activated by extracellular protons. ASIC proteins are a subfamily of the ENaC/Deg superfamily of ion channels. To date five proteins of the ASIC family have been identified that arise from four genes, ASIC1, ASIC2, ASIC3, and ASIC4. ASIC1a, 1b and 2a, 2b are splice variants. ASICs are trimeric and can be made up of different combinations of subunits. ASIC2b is non functional on its own but modulates channel activity when participating in heteromultimers. ASIC4 has no known function. All ASICs are expressed in the peripheral nervous system while ASIC1a, 2a, 2b and 4 are expressed in the central nervous system. ASICs are Na+ permeable with ASIC1a showing low Ca++ permeability. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ASIC1 acid sensing ion channel subunit 1 ACCN2 BNaC2, hBNaC2 12q13.12
ASIC2 acid sensing ion channel subunit 2 ACCN, ACCN1 ASIC2a, BNC1, BNaC1, hBNaC1, MDEG 17q11.2-q12
ASIC3 acid sensing ion channel subunit 3 ACCN3 TNaC1, DRASIC 7q36.1
ASIC4 acid sensing ion channel subunit family member 4 ACCN4 BNAC4 2q35
ASIC5 acid sensing ion channel subunit family member 5 ACCN5 INAC, HINAC 4q32.1