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Gene Family: Potassium two pore domain channel subfamily K (KCNK)

Also known as : "K2p", "Tandem pore domain potassium channels", "Tandem of P domains in a weak inward rectifying K+ channel family", "Two-P potassium channels", "Potassium channel, two pore domain subfamily K"

Tandem pore domain potassium channel: The two-pore-domain potassium channel a family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification. These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the alpha subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier alpha subunits and thus form dimers in the membrane. [Source: Wikipedia]

Genes contained within the family: 15

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
KCNK1 potassium two pore domain channel subfamily K member 1 K2p1.1, DPK, TWIK-1 1q42.2
KCNK2 potassium two pore domain channel subfamily K member 2 K2p2.1, TREK-1 1q41
KCNK3 potassium two pore domain channel subfamily K member 3 K2p3.1, TASK, TASK-1 2p23.3
KCNK4 potassium two pore domain channel subfamily K member 4 K2p4.1, TRAAK 11q13.1
KCNK5 potassium two pore domain channel subfamily K member 5 K2p5.1, TASK-2 6p21.2
KCNK6 potassium two pore domain channel subfamily K member 6 K2p6.1, TWIK-2 19q13.2
KCNK7 potassium two pore domain channel subfamily K member 7 K2p7.1 11q13.1
KCNK9 potassium two pore domain channel subfamily K member 9 K2p9.1, TASK3, TASK-3 8q24.3
KCNK10 potassium two pore domain channel subfamily K member 10 K2p10.1, TREK-2, TREK2, PPP1R97 14q31.3
KCNK12 potassium two pore domain channel subfamily K member 12 THIK-2, THIK2, K2p12.1 2p16.3
KCNK13 potassium two pore domain channel subfamily K member 13 K2p13.1, THIK-1, THIK1 14q32.11
KCNK15 potassium two pore domain channel subfamily K member 15 KCNK11, KCNK14 K2p15.1, dJ781B1.1, KT3.3, KIAA0237, TASK5, TASK-5 20q13.12
KCNK16 potassium two pore domain channel subfamily K member 16 K2p16.1, TALK-1, TALK1 6p21.2
KCNK17 potassium two pore domain channel subfamily K member 17 K2p17.1, TALK-2, TALK2, TASK4, TASK-4 6p21.2
KCNK18 potassium two pore domain channel subfamily K member 18 K2p18.1, TRESK-2, TRESK2, TRESK, TRIK 10q25.3