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Gene Family: Cyclic nucleotide gated channels (CNG)

Also known as : "Cyclic nucleotide-gated ion channels", "CNG channels"

Cyclic nucleotide-gated ion channel: Cyclic nucleotide-gated ion channels or CNG channels are ion channels that function in response to the binding of cyclic nucleotides. CNG channels are nonselective cation channels that are found in the membranes of various tissue and cell types, and are significant in sensory transduction as well as cellular development. Their function can be the result of a combination of the binding of cyclic nucleotides (cGMP and cAMP) and either a depolarization or a hyperpolarization event. Initially discovered in the cells that make up the retina of the eye, CNG channels have been found in many different cell types across both the animal and the plant kingdoms. CNG channels have a very complex structure with various subunits and domains that play a critical role in their function. CNG channels are significant in the function of various sensory pathways including vision and olfaction, as well as in other key cellular functions such as hormone release and chemotaxis. [Source: Wikipedia]

Genes contained within the family: 10

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CNGA1 cyclic nucleotide gated channel alpha 1 CNCG1, CNCG RCNC1, RCNCa, CNG1, RP49 4p12
CNGA2 cyclic nucleotide gated channel alpha 2 CNCA1, CNCA CNG2, OCNC1, OCNCa, OCNCALPHA, OCNCalpha, FLJ46312 Xq28
CNGA3 cyclic nucleotide gated channel alpha 3 CNCG3, ACHM2 CCNC1, CCNCa, CNG3 2q11.2
CNGA4 cyclic nucleotide gated channel alpha 4 CNCA2, CNGB2 OCNC2, OCNCb, CNG5 11p15.4
CNGB1 cyclic nucleotide gated channel beta 1 CNCG2, CNCG3L RCNC2, RCNCb, GARP, GAR1, CNGB1B, RP45 16q21
CNGB3 cyclic nucleotide gated channel beta 3 ACHM3, ACHM1, RMCH 8q21.3
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 BCNG1 BCNG-1, HAC-2 5p12
HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 BCNG2 BCNG-2, HAC-1 19p13.3
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 KIAA1535 1q22
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 15q24.1