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Gene Family: Transient receptor potential cation channels (TRP)

Transient receptor potential channel: Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ( "C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. In the body, some TRP channels are thought to behave like microscopic thermometers and used in animals to sense hot or cold. Some TRP channels are activated by molecules found in spices like garlic ( allicin ), chilli pepper ( capsaicin ), wasabi ( allyl isothiocyanate ); others are activated by menthol, camphor, peppermint, and cooling agents; yet others are activated by molecules found in cannabis (i.e., THC, CBD and CBN ). Some act as sensors of osmotic pressure, volume, stretch, and vibration. These ion channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels were initially discovered in trp -mutant strain of the fruit fly Drosophila. Later, TRP channels were found in vertebrates where they are ubiquitously expressed in many cell types and tissues. Most TRP channels are composed of 6 membrane -spanning helices with intracellular N- and C-termini. Mammalian TRP channels are activated and regulated by a wide variety of stimuli and are expressed throughout the body. [Source: Wikipedia]

Genes contained within the family: 28

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
TRPA1 transient receptor potential cation channel subfamily A member 1 ANKTM1 8q21.11
TRPC1 transient receptor potential cation channel subfamily C member 1 HTRP-1 3q23
TRPC2 transient receptor potential cation channel subfamily C member 2, pseudogene 11p15.4
TRPC3 transient receptor potential cation channel subfamily C member 3 4q27
TRPC4 transient receptor potential cation channel subfamily C member 4 HTRP4, TRP4 13q13.3
TRPC5 transient receptor potential cation channel subfamily C member 5 PPP1R159 Xq23
TRPC6 transient receptor potential cation channel subfamily C member 6 FSGS2 TRP6 11q22.1
TRPC7 transient receptor potential cation channel subfamily C member 7 5q31.1
MCOLN1 mucolipin 1 TRPM-L1, MSTP080, MST080, MLIV, TRPML1, ML4 19p13.2
MCOLN2 mucolipin 2 FLJ36691, TRP-ML2, TRPML2 1p22.3
MCOLN3 mucolipin 3 TRP-ML3, TRPML3, FLJ11006 1p22.3
TRPM1 transient receptor potential cation channel subfamily M member 1 MLSN1 LTRPC1, CSNB1C 15q13.3
TRPM2 transient receptor potential cation channel subfamily M member 2 TRPC7 KNP3, LTRPC2, NUDT9L1, NUDT9H, EREG1 21q22.3
TRPM3 transient receptor potential cation channel subfamily M member 3 KIAA1616, LTRPC3, GON-2 9q21.12-q21.13
TRPM4 transient receptor potential cation channel subfamily M member 4 FLJ20041 19q13.3
TRPM5 transient receptor potential cation channel subfamily M member 5 LTRPC5, MTR1 11p15.5
TRPM6 transient receptor potential cation channel subfamily M member 6 HOMG, HSH CHAK2, FLJ22628 9q21.13
TRPM7 transient receptor potential cation channel subfamily M member 7 CHAK1, LTRPC7, TRP-PLIK 15q21.2
TRPM8 transient receptor potential cation channel subfamily M member 8 2q37.1
PKD2 polycystin 2, transient receptor potential cation channel TRPP2, Pc-2, PC2, PKD4 4q22.1
PKD2L1 polycystin 2 like 1, transient receptor potential cation channel PKD2L, PKDL TRPP3, PCL 10q24.31
PKD2L2 polycystin 2 like 2, transient receptor potential cation channel TRPP5 5q31.2
TRPV1 transient receptor potential cation channel subfamily V member 1 VR1 17p13.2
TRPV2 transient receptor potential cation channel subfamily V member 2 VRL, VRL-1, VRL1 17p11.2
TRPV3 transient receptor potential cation channel subfamily V member 3 VRL3 17p13.2
TRPV4 transient receptor potential cation channel subfamily V member 4 OTRPC4, TRP12, VROAC, VRL-2, VR-OAC, CMT2C 12q24.11
TRPV5 transient receptor potential cation channel subfamily V member 5 ECAC1 CaT2 7q34
TRPV6 transient receptor potential cation channel subfamily V member 6 ECAC2 CaT1 7q34