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Gene Family: Melanocortin receptors

A subset of : Peptide receptors

Melanocortin receptor: Melanocortin receptors are members of the rhodopsin family of 7-transmembrane G protein-coupled receptors. There are five known members of the melanocortin receptor system each with differing specificities for melanocortins : MC1R. MC1R is associated with pigmentation genetics. MC2R. MC2R is also known as the ACTH receptor or corticotropin receptor because it is specific for ACTH alone. MC3R. MC3R MC4R. Defects in MC4R are a cause of autosomal dominant obesity, accounting for 6% of all cases of early-onset obesity. MC5R. MC5R These receptors are inhibited by endogenous inverse agonists agouti signalling peptide and agouti-related peptide, and activated by synthetic (i.e. afamelanotide ) and endogenous agonist melanocyte-stimulating hormones. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MC1R melanocortin 1 receptor MSH-R 16q24.3
MC2R melanocortin 2 receptor ACTHR 18p11.2
MC3R melanocortin 3 receptor MC3 20q13.2
MC4R melanocortin 4 receptor 18q21.32
MC5R melanocortin 5 receptor 18p11.21