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Gene Family: Dopamine receptors (DRD)

A subset of : Amine receptors

Dopamine receptor: Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DRD1 dopamine receptor D1 5q35.2
DRD2 dopamine receptor D2 11q23.2
DRD3 dopamine receptor D3 3q13.31
DRD4 dopamine receptor D4 11p15.5
DRD5 dopamine receptor D5 DRD1L2 DRD1B 4p16.1