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Gene Family: Cholinergic receptors muscarinic (CHRM)

Also known as : "Muscarinic acetylcholine receptors", "Muscarinic receptors", "mAChRs"

Muscarinic acetylcholine receptor: Muscarinic receptors, or mAChRs, are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system. Muscarinic receptors were named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpine and scopolamine ) manipulate these two distinct receptors by acting as selective agonists or antagonists. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CHRM1 cholinergic receptor muscarinic 1 11q12.3
CHRM2 cholinergic receptor muscarinic 2 7q33
CHRM3 cholinergic receptor muscarinic 3 1q43
CHRM4 cholinergic receptor muscarinic 4 11p11.2
CHRM5 cholinergic receptor muscarinic 5 15q14

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