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Gene Family: Cholinergic receptors nicotinic subunits (CHRN)

Nicotinic acetylcholine receptor: Nicotinic acetylcholine receptors, or nAChRs, are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels and do not use second messengers (as metabotropic receptors do). Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor - muscarinic acetylcholine receptor (mAChR) - nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic." In insects, the cholinergic system is limited to the central nervous system. In contrast, neuronal receptors are found in both the central nervous system and the peripheral nervous system of mammals. Mammalian neuromuscular receptors are found in the neuromuscular junctions of somatic muscles ; stimulation of these receptors causes muscular contraction. [Source: Wikipedia]

Genes contained within the family: 16

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CHRNA1 cholinergic receptor nicotinic alpha 1 subunit CHRNA 2q31.1
CHRNA2 cholinergic receptor nicotinic alpha 2 subunit 8p21.2
CHRNA3 cholinergic receptor nicotinic alpha 3 subunit 15q25.1
CHRNA4 cholinergic receptor nicotinic alpha 4 subunit EBN, EBN1 BFNC 20q13.33
CHRNA5 cholinergic receptor nicotinic alpha 5 subunit 15q25.1
CHRNA6 cholinergic receptor nicotinic alpha 6 subunit 8p11.21
CHRNA7 cholinergic receptor nicotinic alpha 7 subunit 15q13.3
CHRNA9 cholinergic receptor nicotinic alpha 9 subunit NACHRA9 4p14
CHRNA10 cholinergic receptor nicotinic alpha 10 subunit 11p15.4
CHRNB1 cholinergic receptor nicotinic beta 1 subunit CHRNB 17p13.1
CHRNB2 cholinergic receptor nicotinic beta 2 subunit 1q21.3
CHRNB3 cholinergic receptor nicotinic beta 3 subunit 8p11.21
CHRNB4 cholinergic receptor nicotinic beta 4 subunit 15q25.1
CHRND cholinergic receptor nicotinic delta subunit ACHRD 2q37.1
CHRNE cholinergic receptor nicotinic epsilon subunit ACHRE 17p13.2
CHRNG cholinergic receptor nicotinic gamma subunit ACHRG 2q37.1