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Gene Family: TCF/LEF transcription factor family

Also known as : "TCF/LEF family"

TCF/LEF family: The TCF/LEF family is a group of transcription factors which bind to DNA through a high mobility group domain. They are involved in the Wnt signaling pathway, where they recruit the coactivator beta-catenin to enhancer elements of genes they target. They can also recruit members of the Groucho family of corepressors. [Source: Wikipedia]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
LEF1 lymphoid enhancer binding factor 1 TCF1ALPHA, TCF10, TCF7L3 4q25
TCF7 transcription factor 7 TCF-1 5q31.1
TCF7L1 transcription factor 7 like 1 TCF3 2p11.2
TCF7L2 transcription factor 7 like 2 TCF4 TCF-4 10q25.2-q25.3

Publications

24413017,26214741,23024173