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Gene Family: M13 metallopeptidases

Also known as : "Neprilysins"

M13 metallopeptidases: These genes encode zinc dependent metallopeptidases in which two of the zinc ligands are histidines in a 'HEXXH' motif. [Source: MEROPS, Rawlings et al]

Genes contained within the family: 7

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ECEL1 endothelin converting enzyme like 1 XCE, DINE 2q37.1
ECE1 endothelin converting enzyme 1 ECE 1p36.12
ECE2 endothelin converting enzyme 2 KIAA0604, MGC2408 3q27.1
KEL Kell blood group, metallo-endopeptidase ECE3, CD238 7q34
MME membrane metalloendopeptidase CALLA, CD10, NEP 3q25.2
MMEL1 membrane metalloendopeptidase like 1 MMEL2 SEP, NL1, NL2, NEPII 1p36.32
PHEX phosphate regulating endopeptidase homolog X-linked HYP, HPDR PEX, HPDR1, HYP1, XLH Xp22.11

Comments

PLEASE NOTE: THIS GENE FAMILY HAS NOT BEEN REVIEWED BY OUR SCIENTIFIC EXPERT ADVISORS YET

Publications

18215274,24395329