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Gene Family: m6A methyltransferase complex

Also known as : "m6A writer complex", "RNA methyltransferase complex", "METTL3-METTL14 methyltransferase complex", "WMM complex"

m6A methyltransferase complex:: N6-methyladenosine modification in mRNA influences mRNA splicing, export, localization, translation, and stability. The m6A writer complex is located in the nuclear speckle, and catalyses the transfer of methyl groups from S-adenosylmethionine (SAM) to the specific adenines on the target RNAs. METTL3 and METTL14 are the catalytic subunits in this complex. [Source: Maity and Das, 2016]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
VIRMA vir like m6A methyltransferase associated KIAA1429 DKFZP434I116, fSAP121 8q22.1
METTL3 methyltransferase like 3 Spo8, M6A, MT-A70 14q11.2
METTL14 methyltransferase like 14 KIAA1627 4q26
WTAP WT1 associated protein KIAA0105, MGC3925, Mum2 6q25.3

Publications

24981863,24316715,27627798